Serum ceruloplasmin levels correlate negatively with liver fibrosis in males with chronic hepatitis B: a new noninvasive model for predicting liver fibrosis in HBV-related liver disease

This study aimed to investigate associations between ceruloplasmin (CP) levels, inflammation grade and fibrosis stages in patients with chronic hepatitis B (CHB) and to establish a noninvasive model to predict cirrhosis. Liver biopsy samples and sera were collected from 198 CHB patients randomized i...

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Veröffentlicht in:	PloS one 2013-10, Vol.8 (10), p.e77942
Hauptverfasser:	Zeng, Da-Wu, Liu, Yu-Rui, Zhang, Jie-Min, Zhu, Yue-Yong, Lin, Su, You, Jia, Li, You-Bing, Chen, Jing, Zheng, Qi, Jiang, Jia-Ji, Dong, Jing
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age Alanine Alanine transaminase Aspartate aminotransferase Biomarkers Biomarkers - blood Biopsy Ceruloplasmin Ceruloplasmin - metabolism Cirrhosis Copper Correlation analysis Diagnostic systems Female Females Fibrosis Hepatitis Hepatitis B Hepatitis B virus Hepatitis B, Chronic - blood Hepatitis B, Chronic - diagnosis Hospitals Humans Immunoassays Infections Inflammation Interferon Laboratories Liver Liver cirrhosis Liver Cirrhosis - blood Liver Cirrhosis - diagnosis Liver Cirrhosis - virology Liver diseases Male Males Mathematical models Middle Aged Multivariate Analysis Patients Platelets Prothrombin Quality Regression analysis Retrospective Studies ROC Curve Sex differences α-Fetoprotein
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