Reduction of decoy receptor 3 enhances TRAIL-mediated apoptosis in pancreatic cancer

Most human pancreatic cancer cells are resistant to tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis. However, the mechanisms by which pancreatic cancer cells utilize their extracellular molecules to counteract the proapoptotic signaling mediated by the TNF fa...

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Veröffentlicht in:	PloS one 2013-10, Vol.8 (10), p.e74272
Hauptverfasser:	Wang, Wei, Zhang, Mei, Sun, Weimin, Yang, Shanmin, Su, Ying, Zhang, Hengshan, Liu, Chaomei, Li, Xinfeng, Lin, Ling, Kim, Sunghee, Okunieff, Paul, Zhang, Zhenhuan, Zhang, Lurong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antimetabolites, Antineoplastic - pharmacology Apoptosis Apoptosis - drug effects Apoptosis - genetics Cancer Cancer therapies Cell Line, Tumor Deoxycytidine - administration & dosage Deoxycytidine - analogs & derivatives Deoxycytidine - pharmacology Disease Models, Animal Gemcitabine Gene amplification Gene Expression Regulation, Neoplastic - drug effects Humans In vivo methods and tests Kinases Laboratories Ligands Mice Oncology Pancreatic cancer Pancreatic Neoplasms - genetics Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - pathology Protein Binding Receptors, Tumor Necrosis Factor, Member 6b - genetics Receptors, Tumor Necrosis Factor, Member 6b - metabolism Reduction Resistance factors RNA Interference Signaling siRNA Surgery TNF-Related Apoptosis-Inducing Ligand - metabolism TRAIL protein Tumor Burden - drug effects Tumor Burden - genetics Tumor cells Tumor necrosis factor Tumor Necrosis Factor Ligand Superfamily Member 14 - metabolism Tumor necrosis factor-TNF Tumors Xenograft Model Antitumor Assays
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