Inhibition of influenza H7 hemagglutinin-mediated entry

The recent outbreak of H7N9 influenza in China is of high concern to public health. H7 hemagglutinin (HA) plays a critical role in influenza entry and thus HA presents an attractive target for antivirals. Previous studies have suggested that the small molecule tert-butyl hydroquinone (TBHQ) inhibits...

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Veröffentlicht in:	PloS one 2013-10, Vol.8 (10), p.e76363
Hauptverfasser:	Antanasijevic, Aleksandar, Cheng, Han, Wardrop, Duncan J, Rong, Lijun, Caffrey, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Antiviral agents Base Sequence Biochemistry Cell culture China - epidemiology Conformation Disease Outbreaks - prevention & control Fatalities Food preservatives Health aspects Hemagglutinin Glycoproteins, Influenza Virus - genetics Hemagglutinin Glycoproteins, Influenza Virus - metabolism Hemagglutinins Humans Hydroquinone Hydroquinones - pharmacology Immunogenicity Immunology Influenza Influenza A Virus, H7N9 Subtype Influenza, Human - epidemiology Influenza, Human - prevention & control Inhibitory Concentration 50 Lectins Ligands Membrane fusion Molecular Sequence Data Monoclonal antibodies NMR Nuclear magnetic resonance Nuclear Magnetic Resonance, Biomolecular Outbreaks Penicillin pH effects Proteins Proteolysis Public health Sequence Analysis, DNA Swine flu t-Butylhydroquinone Virus Internalization - drug effects Viruses
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