BIN1 is decreased in sporadic but not familial Alzheimer's disease or in aging

Bridging integrator 1 (BIN1) has been implicated in sporadic Alzheimer's disease (AD) by a number of genome wide association studies (GWAS) in a variety of populations. Here we measured BIN1 in frontal cortex samples from 24 sporadic AD and 24 age-matched non-dementia brains and correlated the...

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Veröffentlicht in:	PloS one 2013-10, Vol.8 (10), p.e78806
Hauptverfasser:	Glennon, Elizabeth B C, Whitehouse, Isobel J, Miners, J Scott, Kehoe, Patrick G, Love, Seth, Kellett, Katherine A B, Hooper, Nigel M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adapter proteins Adaptor Proteins, Signal Transducing - deficiency Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Adult Advertising executives Age Aged Aged, 80 and over Aging Aging - metabolism Alzheimer Disease - metabolism Alzheimer Disease - physiopathology Alzheimer's disease Amyloid beta-protein Amyloid precursor protein Brain Brain research Cell cycle Cell Line, Tumor Cellular biology Comparative analysis Correlation Cortex (frontal) Data processing Dementia Dementia disorders Endocytosis Female Gene Expression Regulation Gene Knockdown Techniques Genes Genetic aspects Genome-wide association studies Genomes Humans Male Metabolism Middle Aged Neurodegeneration Neurodegenerative diseases Neurosciences Nuclear Proteins - deficiency Nuclear Proteins - genetics Nuclear Proteins - metabolism Pathogenesis Peptides Pollution load Rodents siRNA Tau protein Tumor Suppressor Proteins - deficiency Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism
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