Apoptosis signal-regulating kinase 1 is involved in WISP-1-promoted cell motility in human oral squamous cell carcinoma cells
Oral squamous cell carcinoma (OSCC) has a tendency to migrate and metastasize. WNT1-inducible signaling pathway protein 1 (WISP-1) is a cysteine-rich protein that belongs to the Cyr61, CTGF, Nov (CCN) family of matrix cellular proteins. The effect of WISP-1 on human OSCC cells, however, is unknown....
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| creator | Chuang, Jing-Yuan Chang, An-Chen Chiang, I-Ping Tsai, Ming-Hsui Tang, Chih-Hsin |
| description | Oral squamous cell carcinoma (OSCC) has a tendency to migrate and metastasize. WNT1-inducible signaling pathway protein 1 (WISP-1) is a cysteine-rich protein that belongs to the Cyr61, CTGF, Nov (CCN) family of matrix cellular proteins. The effect of WISP-1 on human OSCC cells, however, is unknown. Here, we showed that WISP-1 increased cell migration and intercellular adhesion molecule-1 (ICAM-1) expression in OSCC cells. Pretreatment of cells with integrin αvβ3 monoclonal antibody (mAb) significantly abolished WISP-1-induced cell migration and ICAM-1 expression. On the other hand, WISP-1-mediated cell motility and ICAM-1 upregulation were attenuated by ASK1, JNK, and p38 inhibitor. Furthermore, WISP-1 also enhanced activator protein 1 (AP-1) activation, and the integrin αvβ3 mAb, and ASK1, JNK, and p38 inhibitors reduced WISP-1-mediated AP-1 activation. Moreover, WISP-1 and ICAM-1 expression correlated with the tumor stage of patients with OSCC. Our results indicate that WISP-1 enhances the migration of OSCC cells by increasing ICAM-1 expression through the αvβ3 integrin receptor and the ASK1, JNK/p38, and AP-1 signal transduction pathways. |
| doi_str_mv | 10.1371/journal.pone.0078022 |
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WNT1-inducible signaling pathway protein 1 (WISP-1) is a cysteine-rich protein that belongs to the Cyr61, CTGF, Nov (CCN) family of matrix cellular proteins. The effect of WISP-1 on human OSCC cells, however, is unknown. Here, we showed that WISP-1 increased cell migration and intercellular adhesion molecule-1 (ICAM-1) expression in OSCC cells. Pretreatment of cells with integrin αvβ3 monoclonal antibody (mAb) significantly abolished WISP-1-induced cell migration and ICAM-1 expression. On the other hand, WISP-1-mediated cell motility and ICAM-1 upregulation were attenuated by ASK1, JNK, and p38 inhibitor. Furthermore, WISP-1 also enhanced activator protein 1 (AP-1) activation, and the integrin αvβ3 mAb, and ASK1, JNK, and p38 inhibitors reduced WISP-1-mediated AP-1 activation. Moreover, WISP-1 and ICAM-1 expression correlated with the tumor stage of patients with OSCC. Our results indicate that WISP-1 enhances the migration of OSCC cells by increasing ICAM-1 expression through the αvβ3 integrin receptor and the ASK1, JNK/p38, and AP-1 signal transduction pathways.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0078022</identifier><identifier>PMID: 24205072</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Activation ; Activator protein 1 ; Antibodies, Monoclonal - pharmacology ; Apoptosis ; Arthritis ; Biotechnology ; Breast cancer ; Carcinoma, Squamous Cell - genetics ; Carcinoma, Squamous Cell - metabolism ; CCN Intercellular Signaling Proteins - genetics ; CCN Intercellular Signaling Proteins - metabolism ; Cell adhesion ; Cell adhesion & migration ; Cell Line, Tumor ; Cell migration ; Cell Movement - genetics ; Cell Movement - physiology ; Cellular signal transduction ; Connective tissue growth factor ; CYR61 protein ; Cysteine ; Epidermal growth factor ; Fibroblasts ; Humans ; Immunoglobulins ; Integrin alphaVbeta3 - antagonists & inhibitors ; Integrin alphaVbeta3 - metabolism ; Integrins ; Intercellular adhesion molecule 1 ; Intercellular Adhesion Molecule-1 - genetics ; Intercellular Adhesion Molecule-1 - metabolism ; JNK protein ; Kinases ; Lung cancer ; MAP kinase ; MAP Kinase Kinase Kinase 5 - genetics ; MAP Kinase Kinase Kinase 5 - metabolism ; Medical laboratories ; Medical prognosis ; Metastasis ; Monoclonal antibodies ; Motility ; Oral cancer ; Oral squamous cell carcinoma ; Penicillin ; Proteins ; Proto-Oncogene Proteins - genetics ; Proto-Oncogene Proteins - metabolism ; Rodents ; Signal Transduction ; Signaling ; Squamous cell carcinoma ; Transcription Factor AP-1 - genetics ; Transcription Factor AP-1 - metabolism ; Transcription factors ; Tumorigenesis</subject><ispartof>PloS one, 2013-10, Vol.8 (10), p.e78022-e78022</ispartof><rights>COPYRIGHT 2013 Public Library of Science</rights><rights>2013 Chuang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2013 Chuang et al 2013 Chuang et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c758t-d5f4771751efd0852b94ecd203cd967067600adb62bf7b3c5c3b10636205fad43</citedby><cites>FETCH-LOGICAL-c758t-d5f4771751efd0852b94ecd203cd967067600adb62bf7b3c5c3b10636205fad43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3804520/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3804520/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,865,886,2103,2929,23870,27928,27929,53795,53797</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24205072$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Mohanraj, Rajesh</contributor><creatorcontrib>Chuang, Jing-Yuan</creatorcontrib><creatorcontrib>Chang, An-Chen</creatorcontrib><creatorcontrib>Chiang, I-Ping</creatorcontrib><creatorcontrib>Tsai, Ming-Hsui</creatorcontrib><creatorcontrib>Tang, Chih-Hsin</creatorcontrib><title>Apoptosis signal-regulating kinase 1 is involved in WISP-1-promoted cell motility in human oral squamous cell carcinoma cells</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Oral squamous cell carcinoma (OSCC) has a tendency to migrate and metastasize. WNT1-inducible signaling pathway protein 1 (WISP-1) is a cysteine-rich protein that belongs to the Cyr61, CTGF, Nov (CCN) family of matrix cellular proteins. The effect of WISP-1 on human OSCC cells, however, is unknown. Here, we showed that WISP-1 increased cell migration and intercellular adhesion molecule-1 (ICAM-1) expression in OSCC cells. Pretreatment of cells with integrin αvβ3 monoclonal antibody (mAb) significantly abolished WISP-1-induced cell migration and ICAM-1 expression. On the other hand, WISP-1-mediated cell motility and ICAM-1 upregulation were attenuated by ASK1, JNK, and p38 inhibitor. Furthermore, WISP-1 also enhanced activator protein 1 (AP-1) activation, and the integrin αvβ3 mAb, and ASK1, JNK, and p38 inhibitors reduced WISP-1-mediated AP-1 activation. Moreover, WISP-1 and ICAM-1 expression correlated with the tumor stage of patients with OSCC. Our results indicate that WISP-1 enhances the migration of OSCC cells by increasing ICAM-1 expression through the αvβ3 integrin receptor and the ASK1, JNK/p38, and AP-1 signal transduction pathways.</description><subject>Activation</subject><subject>Activator protein 1</subject><subject>Antibodies, Monoclonal - pharmacology</subject><subject>Apoptosis</subject><subject>Arthritis</subject><subject>Biotechnology</subject><subject>Breast cancer</subject><subject>Carcinoma, Squamous Cell - genetics</subject><subject>Carcinoma, Squamous Cell - metabolism</subject><subject>CCN Intercellular Signaling Proteins - genetics</subject><subject>CCN Intercellular Signaling Proteins - metabolism</subject><subject>Cell adhesion</subject><subject>Cell adhesion & migration</subject><subject>Cell Line, Tumor</subject><subject>Cell migration</subject><subject>Cell Movement - genetics</subject><subject>Cell Movement - physiology</subject><subject>Cellular signal transduction</subject><subject>Connective tissue growth factor</subject><subject>CYR61 protein</subject><subject>Cysteine</subject><subject>Epidermal growth factor</subject><subject>Fibroblasts</subject><subject>Humans</subject><subject>Immunoglobulins</subject><subject>Integrin alphaVbeta3 - 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pharmacology</topic><topic>Apoptosis</topic><topic>Arthritis</topic><topic>Biotechnology</topic><topic>Breast cancer</topic><topic>Carcinoma, Squamous Cell - genetics</topic><topic>Carcinoma, Squamous Cell - metabolism</topic><topic>CCN Intercellular Signaling Proteins - genetics</topic><topic>CCN Intercellular Signaling Proteins - metabolism</topic><topic>Cell adhesion</topic><topic>Cell adhesion & migration</topic><topic>Cell Line, Tumor</topic><topic>Cell migration</topic><topic>Cell Movement - genetics</topic><topic>Cell Movement - physiology</topic><topic>Cellular signal transduction</topic><topic>Connective tissue growth factor</topic><topic>CYR61 protein</topic><topic>Cysteine</topic><topic>Epidermal growth factor</topic><topic>Fibroblasts</topic><topic>Humans</topic><topic>Immunoglobulins</topic><topic>Integrin alphaVbeta3 - antagonists & inhibitors</topic><topic>Integrin alphaVbeta3 - metabolism</topic><topic>Integrins</topic><topic>Intercellular adhesion molecule 1</topic><topic>Intercellular Adhesion Molecule-1 - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chuang, Jing-Yuan</au><au>Chang, An-Chen</au><au>Chiang, I-Ping</au><au>Tsai, Ming-Hsui</au><au>Tang, Chih-Hsin</au><au>Mohanraj, Rajesh</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Apoptosis signal-regulating kinase 1 is involved in WISP-1-promoted cell motility in human oral squamous cell carcinoma cells</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2013-10-21</date><risdate>2013</risdate><volume>8</volume><issue>10</issue><spage>e78022</spage><epage>e78022</epage><pages>e78022-e78022</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Oral squamous cell carcinoma (OSCC) has a tendency to migrate and metastasize. WNT1-inducible signaling pathway protein 1 (WISP-1) is a cysteine-rich protein that belongs to the Cyr61, CTGF, Nov (CCN) family of matrix cellular proteins. The effect of WISP-1 on human OSCC cells, however, is unknown. Here, we showed that WISP-1 increased cell migration and intercellular adhesion molecule-1 (ICAM-1) expression in OSCC cells. Pretreatment of cells with integrin αvβ3 monoclonal antibody (mAb) significantly abolished WISP-1-induced cell migration and ICAM-1 expression. On the other hand, WISP-1-mediated cell motility and ICAM-1 upregulation were attenuated by ASK1, JNK, and p38 inhibitor. Furthermore, WISP-1 also enhanced activator protein 1 (AP-1) activation, and the integrin αvβ3 mAb, and ASK1, JNK, and p38 inhibitors reduced WISP-1-mediated AP-1 activation. Moreover, WISP-1 and ICAM-1 expression correlated with the tumor stage of patients with OSCC. Our results indicate that WISP-1 enhances the migration of OSCC cells by increasing ICAM-1 expression through the αvβ3 integrin receptor and the ASK1, JNK/p38, and AP-1 signal transduction pathways.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>24205072</pmid><doi>10.1371/journal.pone.0078022</doi><tpages>e78022</tpages><oa>free_for_read</oa></addata></record> |
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| issn | 1932-6203 1932-6203 |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Activation Activator protein 1 Antibodies, Monoclonal - pharmacology Apoptosis Arthritis Biotechnology Breast cancer Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - metabolism CCN Intercellular Signaling Proteins - genetics CCN Intercellular Signaling Proteins - metabolism Cell adhesion Cell adhesion & migration Cell Line, Tumor Cell migration Cell Movement - genetics Cell Movement - physiology Cellular signal transduction Connective tissue growth factor CYR61 protein Cysteine Epidermal growth factor Fibroblasts Humans Immunoglobulins Integrin alphaVbeta3 - antagonists & inhibitors Integrin alphaVbeta3 - metabolism Integrins Intercellular adhesion molecule 1 Intercellular Adhesion Molecule-1 - genetics Intercellular Adhesion Molecule-1 - metabolism JNK protein Kinases Lung cancer MAP kinase MAP Kinase Kinase Kinase 5 - genetics MAP Kinase Kinase Kinase 5 - metabolism Medical laboratories Medical prognosis Metastasis Monoclonal antibodies Motility Oral cancer Oral squamous cell carcinoma Penicillin Proteins Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Rodents Signal Transduction Signaling Squamous cell carcinoma Transcription Factor AP-1 - genetics Transcription Factor AP-1 - metabolism Transcription factors Tumorigenesis |
| title | Apoptosis signal-regulating kinase 1 is involved in WISP-1-promoted cell motility in human oral squamous cell carcinoma cells |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-17T06%3A36%3A34IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Apoptosis%20signal-regulating%20kinase%201%20is%20involved%20in%20WISP-1-promoted%20cell%20motility%20in%20human%20oral%20squamous%20cell%20carcinoma%20cells&rft.jtitle=PloS%20one&rft.au=Chuang,%20Jing-Yuan&rft.date=2013-10-21&rft.volume=8&rft.issue=10&rft.spage=e78022&rft.epage=e78022&rft.pages=e78022-e78022&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0078022&rft_dat=%3Cgale_plos_%3EA478172419%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1443691260&rft_id=info:pmid/24205072&rft_galeid=A478172419&rft_doaj_id=oai_doaj_org_article_63d4391f54f44b51a099b1a162a8e8f2&rfr_iscdi=true |