Colon cryptogenesis: asymmetric budding

The process of crypt formation and the roles of Wnt and cell-cell adhesion signaling in cryptogenesis are not well described; but are important to the understanding of both normal and cancer colon crypt biology. A quantitative 3D-microscopy and image analysis technique is used to study the frequency...

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Veröffentlicht in:	PloS one 2013-10, Vol.8 (10), p.e78519-e78519
Hauptverfasser:	Tan, Chin Wee, Hirokawa, Yumiko, Gardiner, Bruce S, Smith, David W, Burgess, Antony W
Format:	Artikel
Sprache:	eng
Schlagworte:	Aberration Adenomatous polyposis coli Adenomatous polyposis coli protein Animals Asymmetry beta Catenin - metabolism Biology Budding Cadherins - metabolism Cancer Cell adhesion Cell adhesion & migration Colon Colon - metabolism Colon - pathology Colon - physiology Colon cancer Colonic Neoplasms - metabolism Colonic Neoplasms - pathology Colorectal cancer Crypts E-cadherin Heterogeneity Image analysis Image processing Immunofluorescence Intestinal Mucosa - metabolism Intestinal Mucosa - pathology Intestinal Mucosa - physiology Medical research Mice Mice, Inbred C57BL Microscopy Mucosa Polyposis coli Rodents Signal Transduction - physiology Signaling Small intestine Wnt protein Wnt Signaling Pathway - physiology β-Catenin
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