Ih tunes theta/gamma oscillations and cross-frequency coupling in an in silico CA3 model

Ih channels are uniquely positioned to act as neuromodulatory control points for tuning hippocampal theta (4-12 Hz) and gamma (25 Hz) oscillations, oscillations which are thought to have importance for organization of information flow. contributes to neuronal membrane resonance and resting membrane...

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Veröffentlicht in:	PloS one 2013-10, Vol.8 (10), p.e76285-e76285
Hauptverfasser:	Neymotin, Samuel A, Hilscher, Markus M, Moulin, Thiago C, Skolnick, Yosef, Lazarewicz, Maciej T, Lytton, William W
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - drug effects Action Potentials - physiology alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid - pharmacology Brain Waves CA3 Region, Hippocampal - physiology Computer Simulation Coupling Excitability Hippocampus Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels - metabolism Information flow Interneurons - drug effects Interneurons - physiology Isoforms Kinases Membrane potential Models, Neurological Multiscale analysis Neuromodulation Neurosciences Oscillations Permeability Pharmacology Physiology Pyramidal Cells - drug effects Pyramidal Cells - pathology Rodents Second messengers Theta Rhythm Theta rhythms Trends Tuning
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