Ih tunes theta/gamma oscillations and cross-frequency coupling in an in silico CA3 model
Ih channels are uniquely positioned to act as neuromodulatory control points for tuning hippocampal theta (4-12 Hz) and gamma (25 Hz) oscillations, oscillations which are thought to have importance for organization of information flow. contributes to neuronal membrane resonance and resting membrane...
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| Veröffentlicht in: | PloS one 2013-10, Vol.8 (10), p.e76285-e76285 |
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| creator | Neymotin, Samuel A Hilscher, Markus M Moulin, Thiago C Skolnick, Yosef Lazarewicz, Maciej T Lytton, William W |
| description | Ih channels are uniquely positioned to act as neuromodulatory control points for tuning hippocampal theta (4-12 Hz) and gamma (25 Hz) oscillations, oscillations which are thought to have importance for organization of information flow. contributes to neuronal membrane resonance and resting membrane potential, and is modulated by second messengers. We investigated oscillatory control using a multiscale computer model of hippocampal CA3, where each cell class (pyramidal, basket, and oriens-lacunosum moleculare cells), contained type-appropriate isoforms of . Our model demonstrated that modulation of pyramidal and basket allows tuning theta and gamma oscillation frequency and amplitude. Pyramidal also controlled cross-frequency coupling (CFC) and allowed shifting gamma generation towards particular phases of the theta cycle, effected via 's ability to set pyramidal excitability. Our model predicts that in vivo neuromodulatory control of allows flexibly controlling CFC and the timing of gamma discharges at particular theta phases. |
| doi_str_mv | 10.1371/journal.pone.0076285 |
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We investigated oscillatory control using a multiscale computer model of hippocampal CA3, where each cell class (pyramidal, basket, and oriens-lacunosum moleculare cells), contained type-appropriate isoforms of . Our model demonstrated that modulation of pyramidal and basket allows tuning theta and gamma oscillation frequency and amplitude. Pyramidal also controlled cross-frequency coupling (CFC) and allowed shifting gamma generation towards particular phases of the theta cycle, effected via 's ability to set pyramidal excitability. Our model predicts that in vivo neuromodulatory control of allows flexibly controlling CFC and the timing of gamma discharges at particular theta phases.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0076285</identifier><identifier>PMID: 24204609</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Action Potentials - drug effects ; Action Potentials - physiology ; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid - pharmacology ; Brain Waves ; CA3 Region, Hippocampal - physiology ; Computer Simulation ; Coupling ; Excitability ; Hippocampus ; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels - metabolism ; Information flow ; Interneurons - drug effects ; Interneurons - physiology ; Isoforms ; Kinases ; Membrane potential ; Models, Neurological ; Multiscale analysis ; Neuromodulation ; Neurosciences ; Oscillations ; Permeability ; Pharmacology ; Physiology ; Pyramidal Cells - drug effects ; Pyramidal Cells - pathology ; Rodents ; Second messengers ; Theta Rhythm ; Theta rhythms ; Trends ; Tuning</subject><ispartof>PloS one, 2013-10, Vol.8 (10), p.e76285-e76285</ispartof><rights>2013 Neymotin et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2013 Neymotin et al 2013 Neymotin et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4415-e8a95c897e3334161785196cbdab7379b1d50bca7503b40dd92ca24c985263043</citedby><cites>FETCH-LOGICAL-c4415-e8a95c897e3334161785196cbdab7379b1d50bca7503b40dd92ca24c985263043</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3799898/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3799898/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24204609$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Cymbalyuk, Gennady</contributor><creatorcontrib>Neymotin, Samuel A</creatorcontrib><creatorcontrib>Hilscher, Markus M</creatorcontrib><creatorcontrib>Moulin, Thiago C</creatorcontrib><creatorcontrib>Skolnick, Yosef</creatorcontrib><creatorcontrib>Lazarewicz, Maciej T</creatorcontrib><creatorcontrib>Lytton, William W</creatorcontrib><title>Ih tunes theta/gamma oscillations and cross-frequency coupling in an in silico CA3 model</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Ih channels are uniquely positioned to act as neuromodulatory control points for tuning hippocampal theta (4-12 Hz) and gamma (25 Hz) oscillations, oscillations which are thought to have importance for organization of information flow. contributes to neuronal membrane resonance and resting membrane potential, and is modulated by second messengers. We investigated oscillatory control using a multiscale computer model of hippocampal CA3, where each cell class (pyramidal, basket, and oriens-lacunosum moleculare cells), contained type-appropriate isoforms of . Our model demonstrated that modulation of pyramidal and basket allows tuning theta and gamma oscillation frequency and amplitude. Pyramidal also controlled cross-frequency coupling (CFC) and allowed shifting gamma generation towards particular phases of the theta cycle, effected via 's ability to set pyramidal excitability. Our model predicts that in vivo neuromodulatory control of allows flexibly controlling CFC and the timing of gamma discharges at particular theta phases.</description><subject>Action Potentials - drug effects</subject><subject>Action Potentials - physiology</subject><subject>alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid - pharmacology</subject><subject>Brain Waves</subject><subject>CA3 Region, Hippocampal - physiology</subject><subject>Computer Simulation</subject><subject>Coupling</subject><subject>Excitability</subject><subject>Hippocampus</subject><subject>Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels - metabolism</subject><subject>Information flow</subject><subject>Interneurons - drug effects</subject><subject>Interneurons - physiology</subject><subject>Isoforms</subject><subject>Kinases</subject><subject>Membrane potential</subject><subject>Models, Neurological</subject><subject>Multiscale analysis</subject><subject>Neuromodulation</subject><subject>Neurosciences</subject><subject>Oscillations</subject><subject>Permeability</subject><subject>Pharmacology</subject><subject>Physiology</subject><subject>Pyramidal Cells - drug effects</subject><subject>Pyramidal Cells - pathology</subject><subject>Rodents</subject><subject>Second messengers</subject><subject>Theta Rhythm</subject><subject>Theta rhythms</subject><subject>Trends</subject><subject>Tuning</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNptUk1rGzEQXUpLk6b9B6UV5NLLOvoYSatLIZi0NQR6aSA3odXKtoxWcqXdQv591_YmJKUXScy8efNm9KrqI8ELwiS52qUxRxMW-xTdAmMpaMNfVedEMVoLitnrZ--z6l0pO4w5a4R4W51RoBgEVufV_WqLhjG6goatG8zVxvS9QalYH4IZfIoFmdghm1Mp9Tq736OL9gHZNO6Djxvk45Q_nMUHbxNaXjPUp86F99WbtQnFfZjvi-ru282v5Y_69uf31fL6trYAhNeuMYrbRknHGAMiiGw4UcK2nWklk6olHcetNZJj1gLuOkWtoWBVw6lgGNhF9fnEuw-p6HkpRRMAqhoKTE6I1QnRJbPT--x7kx90Ml4fAylvtMmDt8FpZoByAQ6EMsC5bGGSxiXlVoKg7tDt69xtbHvXWReHbMIL0peZ6Ld6k_7oaRTVqGYi-DIT5DTtsgy698W6adnRpfGoW0khOagJevkP9P_TwQl1_KLs1k9iCNYHozxW6YNR9GyUqezT80Geih6dwf4CvYu5-g</recordid><startdate>20131018</startdate><enddate>20131018</enddate><creator>Neymotin, Samuel A</creator><creator>Hilscher, Markus M</creator><creator>Moulin, Thiago C</creator><creator>Skolnick, Yosef</creator><creator>Lazarewicz, Maciej T</creator><creator>Lytton, William W</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20131018</creationdate><title>Ih tunes theta/gamma oscillations and cross-frequency coupling in an in silico CA3 model</title><author>Neymotin, Samuel A ; Hilscher, Markus M ; Moulin, Thiago C ; Skolnick, Yosef ; Lazarewicz, Maciej T ; Lytton, William W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4415-e8a95c897e3334161785196cbdab7379b1d50bca7503b40dd92ca24c985263043</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Action Potentials - drug effects</topic><topic>Action Potentials - physiology</topic><topic>alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid - pharmacology</topic><topic>Brain Waves</topic><topic>CA3 Region, Hippocampal - physiology</topic><topic>Computer Simulation</topic><topic>Coupling</topic><topic>Excitability</topic><topic>Hippocampus</topic><topic>Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels - metabolism</topic><topic>Information flow</topic><topic>Interneurons - drug effects</topic><topic>Interneurons - physiology</topic><topic>Isoforms</topic><topic>Kinases</topic><topic>Membrane potential</topic><topic>Models, Neurological</topic><topic>Multiscale analysis</topic><topic>Neuromodulation</topic><topic>Neurosciences</topic><topic>Oscillations</topic><topic>Permeability</topic><topic>Pharmacology</topic><topic>Physiology</topic><topic>Pyramidal Cells - drug effects</topic><topic>Pyramidal Cells - pathology</topic><topic>Rodents</topic><topic>Second messengers</topic><topic>Theta Rhythm</topic><topic>Theta rhythms</topic><topic>Trends</topic><topic>Tuning</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Neymotin, Samuel A</creatorcontrib><creatorcontrib>Hilscher, Markus M</creatorcontrib><creatorcontrib>Moulin, Thiago C</creatorcontrib><creatorcontrib>Skolnick, Yosef</creatorcontrib><creatorcontrib>Lazarewicz, Maciej T</creatorcontrib><creatorcontrib>Lytton, William W</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Neymotin, Samuel A</au><au>Hilscher, Markus M</au><au>Moulin, Thiago C</au><au>Skolnick, Yosef</au><au>Lazarewicz, Maciej T</au><au>Lytton, William W</au><au>Cymbalyuk, Gennady</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ih tunes theta/gamma oscillations and cross-frequency coupling in an in silico CA3 model</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2013-10-18</date><risdate>2013</risdate><volume>8</volume><issue>10</issue><spage>e76285</spage><epage>e76285</epage><pages>e76285-e76285</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Ih channels are uniquely positioned to act as neuromodulatory control points for tuning hippocampal theta (4-12 Hz) and gamma (25 Hz) oscillations, oscillations which are thought to have importance for organization of information flow. contributes to neuronal membrane resonance and resting membrane potential, and is modulated by second messengers. We investigated oscillatory control using a multiscale computer model of hippocampal CA3, where each cell class (pyramidal, basket, and oriens-lacunosum moleculare cells), contained type-appropriate isoforms of . Our model demonstrated that modulation of pyramidal and basket allows tuning theta and gamma oscillation frequency and amplitude. Pyramidal also controlled cross-frequency coupling (CFC) and allowed shifting gamma generation towards particular phases of the theta cycle, effected via 's ability to set pyramidal excitability. Our model predicts that in vivo neuromodulatory control of allows flexibly controlling CFC and the timing of gamma discharges at particular theta phases.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>24204609</pmid><doi>10.1371/journal.pone.0076285</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Action Potentials - drug effects Action Potentials - physiology alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid - pharmacology Brain Waves CA3 Region, Hippocampal - physiology Computer Simulation Coupling Excitability Hippocampus Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels - metabolism Information flow Interneurons - drug effects Interneurons - physiology Isoforms Kinases Membrane potential Models, Neurological Multiscale analysis Neuromodulation Neurosciences Oscillations Permeability Pharmacology Physiology Pyramidal Cells - drug effects Pyramidal Cells - pathology Rodents Second messengers Theta Rhythm Theta rhythms Trends Tuning |
| title | Ih tunes theta/gamma oscillations and cross-frequency coupling in an in silico CA3 model |
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