Antenatal dexamethasone after asphyxia increases neural injury in preterm fetal sheep

Maternal glucocorticoid treatment for threatened premature delivery dramatically improves neonatal survival and short-term morbidity; however, its effects on neurodevelopmental outcome are variable. We investigated the effect of maternal glucocorticoid exposure after acute asphyxia on injury in the...

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Veröffentlicht in:	PloS one 2013-10, Vol.8 (10), p.e77480
Hauptverfasser:	Koome, Miriam E, Davidson, Joanne O, Drury, Paul P, Mathai, Sam, Booth, Lindsea C, Gunn, Alistair Jan, Bennet, Laura
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents - adverse effects Antibiotics Asphyxia Asphyxia - drug therapy Asphyxia - pathology Basal ganglia Basal Ganglia - drug effects Basal Ganglia - pathology Blood pressure Brain Brain damage Brain injury Cell Count Cell Death Cell survival Central nervous system depressants Cerebral blood flow Cerebral Ventricles - drug effects Cerebral Ventricles - pathology Dexamethasone Dexamethasone - adverse effects EEG Electrocardiography Electroencephalography Exposure Female Fetus Fetuses Ganglia Gestation Glucocorticoids Glucose Hippocampus Hippocampus - drug effects Hippocampus - pathology Humidity Hyperglycemia Hypoxia Infant mortality Injections, Intramuscular Ischemia Morbidity Neonates Neurons Neurons - drug effects Neurons - pathology Newborn babies Occlusion Oligodendrocytes Oligodendroglia - drug effects Oligodendroglia - pathology Ovis aries Physiology Pregnancy Premature Birth - pathology Putamen Recovery Seizures Sheep Sheep, Domestic Steroids Steroids (Organic compounds) Studies Substantia alba Surgery Survival Traumatic brain injury Umbilical cord Umbilical Cord - pathology
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