Long term metabolic syndrome induced by a high fat high fructose diet leads to minimal renal injury in C57BL/6 mice

Metabolic syndrome can induce chronic kidney disease in humans. Genetically engineered mice on a C57BL/6 background are highly used for mechanistic studies. Although it has been shown that metabolic syndrome induces cardiovascular lesions in C57BL/6 mice, in depth renal phenotyping has never been pe...

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Veröffentlicht in:	PloS one 2013-10, Vol.8 (10), p.e76703
Hauptverfasser:	Dissard, Romain, Klein, Julie, Caubet, Cécile, Breuil, Benjamin, Siwy, Justyna, Hoffman, Janosch, Sicard, Laurent, Ducassé, Laure, Rascalou, Simon, Payre, Bruno, Buléon, Marie, Mullen, William, Mischak, Harald, Tack, Ivan, Bascands, Jean-Loup, Buffin-Meyer, Bénédicte, Schanstra, Joost P
Format:	Artikel
Sprache:	eng
Schlagworte:	Albuminuria - chemically induced Albuminuria - pathology Albuminuria - urine Animals Blood Glucose - metabolism Body Weight Cholesterol Cholesterol, HDL - blood Cholesterol, LDL - blood Chronic kidney failure Diabetes Diabetes mellitus Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - chemically induced Diabetes Mellitus, Type 2 - pathology Diabetes Mellitus, Type 2 - urine Diabetic nephropathies Diabetic nephropathy Diet Diet, High-Fat Drinking water Electron microscopy Energy Intake Fibrosis Food consumption Food intake Fructose Fructose - adverse effects Genetic engineering Genetically modified organisms High density lipoprotein High fat diet House mouse Hyperfiltration Injuries Injury analysis Inulin Kidney - metabolism Kidney - pathology Kidney diseases Kidneys Lesions Life sciences Lipoproteins (high density) Lipoproteins (low density) Liver Liver - metabolism Liver - pathology Low density lipoprotein Low density lipoproteins Male Medical research Metabolic disorders Metabolic syndrome Metabolic Syndrome - chemically induced Metabolic Syndrome - pathology Metabolic Syndrome - urine Mice Mice, Inbred C57BL Mutation Nephropathy Obesity Phenotyping Proteome - metabolism Proteomics Renal function Rodents Structure-function relationships Thickening Triglycerides Triglycerides - blood Type 2 diabetes Water consumption
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