Identification of semicarbazones, thiosemicarbazones and triazine nitriles as inhibitors of Leishmania mexicana cysteine protease CPB

Cysteine proteases of the papain superfamily are present in nearly all eukaryotes. They play pivotal roles in the biology of parasites and inhibition of cysteine proteases is emerging as an important strategy to combat parasitic diseases such as sleeping sickness, Chagas' disease and leishmania...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2013-10, Vol.8 (10), p.e77460
Hauptverfasser:	Schröder, Jörg, Noack, Sandra, Marhöfer, Richard J, Mottram, Jeremy C, Coombs, Graham H, Selzer, Paul M
Format:	Artikel
Sprache:	eng
Schlagworte:	African trypanosomiasis Analysis Binding Sites Catalytic Domain Cathepsin B Cathepsins Cyanide Cyanides Cysteine Cysteine Proteases - chemistry Cysteine Proteases - metabolism Cysteine proteinase Cysteine Proteinase Inhibitors - chemistry Cysteine Proteinase Inhibitors - pharmacology Cystine Docking Drug development Drug Discovery Enzymes Eukaryotes High-throughput screening High-Throughput Screening Assays Homology Inhibition Inhibitors Inhibitory Concentration 50 Lead compounds Leishmania mexicana Leishmania mexicana - drug effects Leishmania mexicana - enzymology Leishmaniasis Libraries Life sciences Ligands Medical screening Models, Molecular Molecular Docking Simulation Molecular Structure Nitriles Nitriles - chemistry Nitriles - pharmacology Papain Parasites Parasitic diseases Parasitology Protease Proteases Protein Binding Proteins Recombinant Proteins - chemistry Recombinant Proteins - metabolism Semicarbazones - chemistry Semicarbazones - pharmacology Structural members Thiols Thiosemicarbazones - chemistry Thiosemicarbazones - pharmacology Triazine Vector-borne diseases
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!