Discovery of Mycobacterium tuberculosis protein tyrosine phosphatase B (PtpB) inhibitors from natural products

Protein tyrosine phosphatase B (PtpB) is one of the virulence factors secreted into the host cell by Mycobacterium tuberculosis. PtpB attenuates host immune defenses by interfering with signal transduction pathways in macrophages and, therefore, it is considered a promising target for the developmen...

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Veröffentlicht in:	PloS one 2013-10, Vol.8 (10), p.e77081
Hauptverfasser:	Mascarello, Alessandra, Mori, Mattia, Chiaradia-Delatorre, Louise Domeneghini, Menegatti, Angela Camila Orbem, Delle Monache, Franco, Ferrari, Franco, Yunes, Rosendo Augusto, Nunes, Ricardo José, Terenzi, Hernán, Botta, Bruno, Botta, Maurizio
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Bacterial Proteins - antagonists & inhibitors Bacterial Proteins - metabolism Binding sites Biological Products - chemistry Biological Products - pharmacology Cellular signal transduction Competition Drug development Drug Discovery Drug therapy Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Enzymes Humans Immunosuppressive agents Inhibitors Inhibitory Concentration 50 Kinetics Libraries Macrophages Medical research Medical screening Models, Molecular Molecular Sequence Data Mycobacterium tuberculosis Mycobacterium tuberculosis - drug effects Mycobacterium tuberculosis - enzymology Natural products Peptide Mapping Phenols (Class of compounds) Phosphatase Phosphatases Protein Binding - drug effects Protein Tyrosine Phosphatase, Non-Receptor Type 1 - antagonists & inhibitors Protein Tyrosine Phosphatase, Non-Receptor Type 1 - metabolism Protein Tyrosine Phosphatases - antagonists & inhibitors Protein Tyrosine Phosphatases - chemistry Protein-tyrosine-phosphatase Proteins Proteolysis Tuberculosis Tyrosine Virulence Virulence factors
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