Regulation of mammalian autophagy by class II and III PI 3-kinases through PI3P synthesis

Synthesis of phosphatidylinositol-3-phosphate (PI3P) by Vps34, a class III phosphatidylinositol 3-kinase (PI3K), is critical for the initial steps of autophagosome (AP) biogenesis. Although Vps34 is the sole source of PI3P in budding yeast, mammalian cells can produce PI3P through alternate pathways...

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Veröffentlicht in:	PloS one 2013-10, Vol.8 (10), p.e76405-e76405
Hauptverfasser:	Devereaux, Kelly, Dall'Armi, Claudia, Alcazar-Roman, Abel, Ogasawara, Yuta, Zhou, Xiang, Wang, Fan, Yamamoto, Akitsugu, De Camilli, Pietro, Di Paolo, Gilbert
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase Aging Analysis Animals Autophagy Autophagy - physiology Biochemical analysis Biodegradation Biology Biosynthesis Brain research Cell death Cell Line Cells (Biology) Class II Phosphatidylinositol 3-Kinases - genetics Class II Phosphatidylinositol 3-Kinases - metabolism Class III Phosphatidylinositol 3-Kinases - genetics Class III Phosphatidylinositol 3-Kinases - metabolism Electron microscopy Embryo fibroblasts Embryos Fibroblasts Gene Knockout Techniques Humans Intracellular Space - metabolism Isoforms Kinases Lipids Lysosomes - metabolism Mammalian cells Mammals Medicine Mice Mice, Knockout Monoclonal antibodies Neurobiology Neurosciences Pathology Phagocytosis Phagosomes - metabolism Phosphatidylinositol Phosphates - biosynthesis Phosphoprotein Phosphatases - metabolism Phosphotransferases Physiological aspects Physiology Protein Binding Protein Phosphatase 2C Proteins Proteolysis Regulators Science Substrates Synthesis Yeast
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