Muscular and systemic correlates of resistance training-induced muscle hypertrophy
To determine relationships between post-exercise changes in systemic [testosterone, growth hormone (GH), insulin like grow factor 1 (IGF-1) and interleukin 6 (IL-6)], or intramuscular [skeletal muscle androgen receptor (AR) protein content and p70S6K phosphorylation status] factors in a moderately-s...
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| creator | Mitchell, Cameron J Churchward-Venne, Tyler A Bellamy, Leeann Parise, Gianni Baker, Steven K Phillips, Stuart M |
| description | To determine relationships between post-exercise changes in systemic [testosterone, growth hormone (GH), insulin like grow factor 1 (IGF-1) and interleukin 6 (IL-6)], or intramuscular [skeletal muscle androgen receptor (AR) protein content and p70S6K phosphorylation status] factors in a moderately-sized cohort of young men exhibiting divergent resistance training-mediated muscle hypertrophy.
Twenty three adult males completed 4 sessions•wk⁻¹ of resistance training for 16 wk. Muscle biopsies were obtained before and after the training period and acutely 1 and 5 h after the first training session. Serum hormones and cytokines were measured immediately, 15, 30 and 60 minutes following the first and last training sessions of the study.
Mean fiber area increased by 20% (range: -7 to 80%; P |
| doi_str_mv | 10.1371/journal.pone.0078636 |
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Twenty three adult males completed 4 sessions•wk⁻¹ of resistance training for 16 wk. Muscle biopsies were obtained before and after the training period and acutely 1 and 5 h after the first training session. Serum hormones and cytokines were measured immediately, 15, 30 and 60 minutes following the first and last training sessions of the study.
Mean fiber area increased by 20% (range: -7 to 80%; P<0.001). Protein content of the AR was unchanged with training (fold change = 1.17 ± 0.61; P=0.19); however, there was a significant correlation between the changes in AR content and fiber area (r=0.60, P=0.023). Phosphorylation of p70S6K was elevated 5 hours following exercise, which was correlated with gains in mean fiber area (r=0.54, P=0.007). There was no relationship between the magnitude of the pre- or post-training exercise-induced changes in free testosterone, GH, or IGF-1 concentration and muscle fiber hypertrophy; however, the magnitude of the post exercise IL-6 response was correlated with muscle hypertrophy (r=0.48, P=0.019).
Post-exercise increases in circulating hormones are not related to hypertrophy following training. Exercise-induced changes in IL-6 correlated with hypertrophy, but the mechanism for the role of IL-6 in hypertrophy is not known. Acute increases, in p70S6K phosphorylation and changes in muscle AR protein content correlated with muscle hypertrophy implicating intramuscular rather than systemic processes in mediating hypertrophy.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0078636</identifier><identifier>PMID: 24130904</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Androgen receptors ; Androgens ; Cohort Studies ; Correlation ; Cytokines ; Ethics ; Exercise ; Gene expression ; Growth hormone ; Growth Hormone - blood ; Growth hormones ; Hormones ; Hormones - blood ; Humans ; Hypertrophy ; Hypertrophy - blood ; Hypertrophy - etiology ; Hypertrophy - pathology ; Insulin ; Insulin-like growth factor I ; Insulin-Like Growth Factor I - analysis ; Interleukin ; Interleukin 6 ; Interleukin-6 - blood ; Interleukins ; Kinesiology ; Male ; Males ; Medical screening ; Metabolism ; Muscle, Skeletal - metabolism ; Muscle, Skeletal - pathology ; Muscles ; Musculoskeletal system ; Phosphorylation ; Physical fitness ; Physical training ; Protein folding ; Protein synthesis ; Proteins ; Receptors, Androgen - analysis ; Receptors, Androgen - metabolism ; Resistance training ; Resistance Training - adverse effects ; Ribosomal Protein S6 Kinases, 70-kDa - metabolism ; Skeletal muscle ; Somatotropin ; Strength training ; Testosterone ; Testosterone - blood ; Training ; Weight Lifting ; Weight training ; Young Adult</subject><ispartof>PloS one, 2013-10, Vol.8 (10), p.e78636-e78636</ispartof><rights>COPYRIGHT 2013 Public Library of Science</rights><rights>2013 Mitchell et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2013 Mitchell et al 2013 Mitchell et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-ce4c5690243dd8cea2f71fc8bf7bc538a3342aa30d6458cfc3e162168dc1ffe63</citedby><cites>FETCH-LOGICAL-c692t-ce4c5690243dd8cea2f71fc8bf7bc538a3342aa30d6458cfc3e162168dc1ffe63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3793973/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3793973/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24130904$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mitchell, Cameron J</creatorcontrib><creatorcontrib>Churchward-Venne, Tyler A</creatorcontrib><creatorcontrib>Bellamy, Leeann</creatorcontrib><creatorcontrib>Parise, Gianni</creatorcontrib><creatorcontrib>Baker, Steven K</creatorcontrib><creatorcontrib>Phillips, Stuart M</creatorcontrib><title>Muscular and systemic correlates of resistance training-induced muscle hypertrophy</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>To determine relationships between post-exercise changes in systemic [testosterone, growth hormone (GH), insulin like grow factor 1 (IGF-1) and interleukin 6 (IL-6)], or intramuscular [skeletal muscle androgen receptor (AR) protein content and p70S6K phosphorylation status] factors in a moderately-sized cohort of young men exhibiting divergent resistance training-mediated muscle hypertrophy.
Twenty three adult males completed 4 sessions•wk⁻¹ of resistance training for 16 wk. Muscle biopsies were obtained before and after the training period and acutely 1 and 5 h after the first training session. Serum hormones and cytokines were measured immediately, 15, 30 and 60 minutes following the first and last training sessions of the study.
Mean fiber area increased by 20% (range: -7 to 80%; P<0.001). Protein content of the AR was unchanged with training (fold change = 1.17 ± 0.61; P=0.19); however, there was a significant correlation between the changes in AR content and fiber area (r=0.60, P=0.023). Phosphorylation of p70S6K was elevated 5 hours following exercise, which was correlated with gains in mean fiber area (r=0.54, P=0.007). There was no relationship between the magnitude of the pre- or post-training exercise-induced changes in free testosterone, GH, or IGF-1 concentration and muscle fiber hypertrophy; however, the magnitude of the post exercise IL-6 response was correlated with muscle hypertrophy (r=0.48, P=0.019).
Post-exercise increases in circulating hormones are not related to hypertrophy following training. Exercise-induced changes in IL-6 correlated with hypertrophy, but the mechanism for the role of IL-6 in hypertrophy is not known. Acute increases, in p70S6K phosphorylation and changes in muscle AR protein content correlated with muscle hypertrophy implicating intramuscular rather than systemic processes in mediating hypertrophy.</description><subject>Adult</subject><subject>Androgen receptors</subject><subject>Androgens</subject><subject>Cohort Studies</subject><subject>Correlation</subject><subject>Cytokines</subject><subject>Ethics</subject><subject>Exercise</subject><subject>Gene expression</subject><subject>Growth hormone</subject><subject>Growth Hormone - blood</subject><subject>Growth hormones</subject><subject>Hormones</subject><subject>Hormones - blood</subject><subject>Humans</subject><subject>Hypertrophy</subject><subject>Hypertrophy - blood</subject><subject>Hypertrophy - etiology</subject><subject>Hypertrophy - pathology</subject><subject>Insulin</subject><subject>Insulin-like growth factor I</subject><subject>Insulin-Like Growth Factor I - analysis</subject><subject>Interleukin</subject><subject>Interleukin 6</subject><subject>Interleukin-6 - blood</subject><subject>Interleukins</subject><subject>Kinesiology</subject><subject>Male</subject><subject>Males</subject><subject>Medical screening</subject><subject>Metabolism</subject><subject>Muscle, Skeletal - metabolism</subject><subject>Muscle, Skeletal - pathology</subject><subject>Muscles</subject><subject>Musculoskeletal system</subject><subject>Phosphorylation</subject><subject>Physical fitness</subject><subject>Physical training</subject><subject>Protein folding</subject><subject>Protein synthesis</subject><subject>Proteins</subject><subject>Receptors, Androgen - analysis</subject><subject>Receptors, Androgen - metabolism</subject><subject>Resistance training</subject><subject>Resistance Training - adverse effects</subject><subject>Ribosomal Protein S6 Kinases, 70-kDa - metabolism</subject><subject>Skeletal muscle</subject><subject>Somatotropin</subject><subject>Strength training</subject><subject>Testosterone</subject><subject>Testosterone - blood</subject><subject>Training</subject><subject>Weight Lifting</subject><subject>Weight training</subject><subject>Young Adult</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNkl1r2zAUhs3YWLtu_2BshsHYLpJJPrIs3wxK2Uego9B93ApFH4mCI6WSPJZ_P7lxSzx6MXRhIT_ve46O3qJ4idEcQ4M_bHwfnOjmO-_0HKGGUaCPilPcQjWjFYLHR_uT4lmMG4RqYJQ-LU4qggG1iJwW19_6KPtOhFI4VcZ9THprZSl9CLoTScfSmzLoaGMSTuoyBWGddauZdaqXWpXbrO90ud7vdEjB79b758UTI7qoX4zfs-Ln508_Lr7OLq--LC7OL2eStlWaSU1kTVtUEVCKSS0q02Aj2dI0S5kbFQCkEgKQoqRm0kjQmFaYMiWxMZrCWfH64LvrfOTjOCLHhFSEoaZuM7E4EMqLDd8FuxVhz72w_PbAhxUXIdncP18y2S6BUASNIrhSjCCBUY0EUmBYQ7LXx7Fav9xqJbXLo-gmptM_zq75yv_m0LTQNpAN3o0Gwd_0Oia-tVHqrhNO-_62b2hboGjo-80_6MO3G6mVyBewzvhcVw6m_Jw0DGqgbCg7f4DKSw0PnbNjbD6fCN5PBJlJ-k9aiT5Gvvh-_f_s1a8p-_aIXWvRpXX0XZ-sd3EKkgMog48xaHM_ZIz4EP27afAh-nyMfpa9On6ge9Fd1uEvoAT_Jg</recordid><startdate>20131009</startdate><enddate>20131009</enddate><creator>Mitchell, Cameron J</creator><creator>Churchward-Venne, Tyler A</creator><creator>Bellamy, Leeann</creator><creator>Parise, Gianni</creator><creator>Baker, Steven K</creator><creator>Phillips, Stuart M</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20131009</creationdate><title>Muscular and systemic correlates of resistance training-induced muscle hypertrophy</title><author>Mitchell, Cameron J ; Churchward-Venne, Tyler A ; Bellamy, Leeann ; Parise, Gianni ; Baker, Steven K ; Phillips, Stuart M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-ce4c5690243dd8cea2f71fc8bf7bc538a3342aa30d6458cfc3e162168dc1ffe63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Androgen receptors</topic><topic>Androgens</topic><topic>Cohort Studies</topic><topic>Correlation</topic><topic>Cytokines</topic><topic>Ethics</topic><topic>Exercise</topic><topic>Gene expression</topic><topic>Growth hormone</topic><topic>Growth Hormone - blood</topic><topic>Growth hormones</topic><topic>Hormones</topic><topic>Hormones - blood</topic><topic>Humans</topic><topic>Hypertrophy</topic><topic>Hypertrophy - blood</topic><topic>Hypertrophy - etiology</topic><topic>Hypertrophy - pathology</topic><topic>Insulin</topic><topic>Insulin-like growth factor I</topic><topic>Insulin-Like Growth Factor I - analysis</topic><topic>Interleukin</topic><topic>Interleukin 6</topic><topic>Interleukin-6 - blood</topic><topic>Interleukins</topic><topic>Kinesiology</topic><topic>Male</topic><topic>Males</topic><topic>Medical screening</topic><topic>Metabolism</topic><topic>Muscle, Skeletal - metabolism</topic><topic>Muscle, Skeletal - pathology</topic><topic>Muscles</topic><topic>Musculoskeletal system</topic><topic>Phosphorylation</topic><topic>Physical fitness</topic><topic>Physical training</topic><topic>Protein folding</topic><topic>Protein synthesis</topic><topic>Proteins</topic><topic>Receptors, Androgen - analysis</topic><topic>Receptors, Androgen - metabolism</topic><topic>Resistance training</topic><topic>Resistance Training - adverse effects</topic><topic>Ribosomal Protein S6 Kinases, 70-kDa - metabolism</topic><topic>Skeletal muscle</topic><topic>Somatotropin</topic><topic>Strength training</topic><topic>Testosterone</topic><topic>Testosterone - blood</topic><topic>Training</topic><topic>Weight Lifting</topic><topic>Weight training</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mitchell, Cameron J</creatorcontrib><creatorcontrib>Churchward-Venne, Tyler A</creatorcontrib><creatorcontrib>Bellamy, Leeann</creatorcontrib><creatorcontrib>Parise, Gianni</creatorcontrib><creatorcontrib>Baker, Steven K</creatorcontrib><creatorcontrib>Phillips, Stuart M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mitchell, Cameron J</au><au>Churchward-Venne, Tyler A</au><au>Bellamy, Leeann</au><au>Parise, Gianni</au><au>Baker, Steven K</au><au>Phillips, Stuart M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Muscular and systemic correlates of resistance training-induced muscle hypertrophy</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2013-10-09</date><risdate>2013</risdate><volume>8</volume><issue>10</issue><spage>e78636</spage><epage>e78636</epage><pages>e78636-e78636</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>To determine relationships between post-exercise changes in systemic [testosterone, growth hormone (GH), insulin like grow factor 1 (IGF-1) and interleukin 6 (IL-6)], or intramuscular [skeletal muscle androgen receptor (AR) protein content and p70S6K phosphorylation status] factors in a moderately-sized cohort of young men exhibiting divergent resistance training-mediated muscle hypertrophy.
Twenty three adult males completed 4 sessions•wk⁻¹ of resistance training for 16 wk. Muscle biopsies were obtained before and after the training period and acutely 1 and 5 h after the first training session. Serum hormones and cytokines were measured immediately, 15, 30 and 60 minutes following the first and last training sessions of the study.
Mean fiber area increased by 20% (range: -7 to 80%; P<0.001). Protein content of the AR was unchanged with training (fold change = 1.17 ± 0.61; P=0.19); however, there was a significant correlation between the changes in AR content and fiber area (r=0.60, P=0.023). Phosphorylation of p70S6K was elevated 5 hours following exercise, which was correlated with gains in mean fiber area (r=0.54, P=0.007). There was no relationship between the magnitude of the pre- or post-training exercise-induced changes in free testosterone, GH, or IGF-1 concentration and muscle fiber hypertrophy; however, the magnitude of the post exercise IL-6 response was correlated with muscle hypertrophy (r=0.48, P=0.019).
Post-exercise increases in circulating hormones are not related to hypertrophy following training. Exercise-induced changes in IL-6 correlated with hypertrophy, but the mechanism for the role of IL-6 in hypertrophy is not known. Acute increases, in p70S6K phosphorylation and changes in muscle AR protein content correlated with muscle hypertrophy implicating intramuscular rather than systemic processes in mediating hypertrophy.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>24130904</pmid><doi>10.1371/journal.pone.0078636</doi><tpages>e78636</tpages><oa>free_for_read</oa></addata></record> |
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| issn | 1932-6203 1932-6203 |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Adult Androgen receptors Androgens Cohort Studies Correlation Cytokines Ethics Exercise Gene expression Growth hormone Growth Hormone - blood Growth hormones Hormones Hormones - blood Humans Hypertrophy Hypertrophy - blood Hypertrophy - etiology Hypertrophy - pathology Insulin Insulin-like growth factor I Insulin-Like Growth Factor I - analysis Interleukin Interleukin 6 Interleukin-6 - blood Interleukins Kinesiology Male Males Medical screening Metabolism Muscle, Skeletal - metabolism Muscle, Skeletal - pathology Muscles Musculoskeletal system Phosphorylation Physical fitness Physical training Protein folding Protein synthesis Proteins Receptors, Androgen - analysis Receptors, Androgen - metabolism Resistance training Resistance Training - adverse effects Ribosomal Protein S6 Kinases, 70-kDa - metabolism Skeletal muscle Somatotropin Strength training Testosterone Testosterone - blood Training Weight Lifting Weight training Young Adult |
| title | Muscular and systemic correlates of resistance training-induced muscle hypertrophy |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-12T23%3A05%3A26IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Muscular%20and%20systemic%20correlates%20of%20resistance%20training-induced%20muscle%20hypertrophy&rft.jtitle=PloS%20one&rft.au=Mitchell,%20Cameron%20J&rft.date=2013-10-09&rft.volume=8&rft.issue=10&rft.spage=e78636&rft.epage=e78636&rft.pages=e78636-e78636&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0078636&rft_dat=%3Cgale_plos_%3EA478353683%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1442480759&rft_id=info:pmid/24130904&rft_galeid=A478353683&rft_doaj_id=oai_doaj_org_article_b8c9b346037d412d840a1050a0d3f874&rfr_iscdi=true |