Adherence as a predictor of the development of class-specific resistance mutations: the Swiss HIV Cohort Study

Non-adherence is one of the strongest predictors of therapeutic failure in HIV-positive patients. Virologic failure with subsequent emergence of resistance reduces future treatment options and long-term clinical success. Prospective observational cohort study including patients starting new class of...

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Veröffentlicht in:	PloS one 2013-10, Vol.8 (10), p.e77691-e77691
Hauptverfasser:	von Wyl, Viktor, Klimkait, Thomas, Yerly, Sabine, Nicca, Dunja, Furrer, Hansjakob, Cavassini, Matthias, Calmy, Alexandra, Bernasconi, Enos, Böni, Jürg, Aubert, Vincent, Günthard, Huldrych F, Bucher, Heiner C, Glass, Tracy R
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome Adhesion Adult AIDS Analysis Anti-Retroviral Agents - pharmacology Antiretroviral agents Antiretroviral drugs Antiretroviral therapy Care and treatment Cohort analysis Confidence intervals Drug resistance Drug Resistance, Viral - genetics Drug Resistance, Viral - physiology Female Genetic aspects Genotype Health aspects Highly active antiretroviral therapy HIV Human immunodeficiency virus Humans Kaplan-Meier Estimate Logistic Models Male Medical research Medical screening Middle Aged Mutation Patient compliance Patients Protease inhibitors Regression analysis Regression models Ribonucleic acid RNA Statistical analysis
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