Effect of Iboga alkaloids on µ-opioid receptor-coupled G protein activation

The iboga alkaloids are a class of small molecules defined structurally on the basis of a common ibogamine skeleton, some of which modify opioid withdrawal and drug self-administration in humans and preclinical models. These compounds may represent an innovative approach to neurobiological investiga...

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Veröffentlicht in:	PloS one 2013-10, Vol.8 (10), p.e77262
Hauptverfasser:	Antonio, Tamara, Childers, Steven R, Rothman, Richard B, Dersch, Christina M, King, Christine, Kuehne, Martin, Bornmann, William G, Eshleman, Amy J, Janowsky, Aaron, Simon, Eric R, Reith, Maarten E A, Alper, Kenneth
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Addictions Alkaloids Animal models Animals Antagonists Autoradiography Binding Biochemistry Brain Brain research Brain slice preparation Bridged-Ring Compounds - pharmacology CHO Cells Cricetulus Detoxification Dopamine Dose-Response Relationship, Drug Drug abuse Drug dosages Drug self-administration Drug therapy Drug tolerance Female Gene Expression Guanosine Guanosine 5'-O-(3-Thiotriphosphate) - pharmacology HEK293 Cells Humans Ibogaine Ibogaine - analogs & derivatives Ibogaine - pharmacology Medicine Membranes Narcotics Neurosciences Opioid receptors Organ Specificity Pharmacology Proteins Psychiatry Psychopharmacology Rats Rats, Sprague-Dawley Receptors, Opioid, mu - agonists Receptors, Opioid, mu - antagonists & inhibitors Receptors, Opioid, mu - genetics Receptors, Opioid, mu - metabolism Substance abuse treatment Substance Withdrawal Syndrome - prevention & control Thalamus Thalamus - drug effects Thalamus - metabolism Withdrawal
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