New agents for targeting of IL-13RA2 expressed in primary human and canine brain tumors

Interleukin 13 receptor alpha 2 (IL-13RA2) is over-expressed in a vast majority of human patients with high-grade astrocytomas like glioblastoma. Spontaneous astrocytomas in dogs resemble human disease and have been proposed as translational model system for investigation of novel therapeutic strate...

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Veröffentlicht in:	PloS one 2013-10, Vol.8 (10), p.e77719-e77719
Hauptverfasser:	Debinski, Waldemar, Dickinson, Peter, Rossmeisl, John H, Robertson, John, Gibo, Denise M
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Antibodies, Monoclonal - therapeutic use Astrocytoma Biotechnology Blotting, Western Brain Brain cancer Brain Neoplasms - drug therapy Brain Neoplasms - metabolism Brain research Brain tumors Cancer therapies Cell Line, Tumor Cell Proliferation - drug effects Choroid plexus Cytokines Cytotoxicity Dogs Electrophoresis, Polyacrylamide Gel Enzyme-Linked Immunosorbent Assay Flow Cytometry Gene therapy Glioblastoma Glioblastoma - drug therapy Glioblastoma - metabolism Gliomas Humans Immunofluorescence Immunohistochemistry Immunoprecipitation Interleukin Interleukin 13 Interleukin-13 Receptor alpha2 Subunit - antagonists & inhibitors Interleukin-13 Receptor alpha2 Subunit - metabolism Interleukins Killing Kinases Lysates Medical prognosis Monoclonal antibodies Nervous system Neuroimaging Neurosurgery Patients Peptides Reagents Receptors Reverse Transcriptase Polymerase Chain Reaction Therapeutic targets Translation Tumor Cells, Cultured Tumors Veterinary colleges Veterinary medicine Western blotting
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