Ablating adult neurogenesis in the rat has no effect on spatial processing: evidence from a novel pharmacogenetic model

The function of adult neurogenesis in the rodent brain remains unclear. Ablation of adult born neurons has yielded conflicting results about emotional and cognitive impairments. One hypothesis is that adult neurogenesis in the hippocampus enables spatial pattern separation, allowing animals to disti...

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Veröffentlicht in:	PLoS genetics 2013-09, Vol.9 (9), p.e1003718-e1003718
Hauptverfasser:	Groves, James O, Leslie, Isla, Huang, Guo-Jen, McHugh, Stephen B, Taylor, Amy, Mott, Richard, Munafò, Marcus, Bannerman, David M, Flint, Jonathan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal memory Animals Anxiety - physiopathology Behavior Cell growth Cognitive Dysfunction - genetics Cognitive Dysfunction - pathology Conditioning, Psychological Fear - physiology Glial Fibrillary Acidic Protein - genetics Glial Fibrillary Acidic Protein - metabolism Hippocampus - metabolism Hippocampus - physiology Maze Learning - physiology Memory - physiology Meta-analysis Neurogenesis Neurogenesis - genetics Neurons - metabolism Pharmacogenetics Rats Rodents Spatial behavior in animals Studies Thymidine Kinase - genetics Thymidine Kinase - metabolism
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