Integration of the unfolded protein and oxidative stress responses through SKN-1/Nrf

The Unfolded Protein Response (UPR) maintains homeostasis in the endoplasmic reticulum (ER) and defends against ER stress, an underlying factor in various human diseases. During the UPR, numerous genes are activated that sustain and protect the ER. These responses are known to involve the canonical...

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Veröffentlicht in:	PLoS genetics 2013-09, Vol.9 (9), p.e1003701-e1003701
Hauptverfasser:	Glover-Cutter, Kira M, Lin, Stephanie, Blackwell, T Keith
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Caenorhabditis elegans Caenorhabditis elegans - genetics Caenorhabditis elegans - metabolism Caenorhabditis elegans Proteins - genetics Cytoplasm - genetics Diabetes Disease DNA-Binding Proteins - genetics Endoplasmic reticulum Endoplasmic Reticulum - genetics Endoplasmic Reticulum - metabolism Endoplasmic Reticulum Stress - genetics Experiments Genes Genetic aspects Genetic transcription Homeostasis Humans Kinases Oxidative stress Oxidative Stress - genetics Physiological aspects Properties Protein folding Protein synthesis Signal Transduction Stress Stress response Transcription factors Transcription Factors - genetics Transcription, Genetic Unfolded Protein Response - genetics
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