Erythropoietin receptor expression is a potential prognostic factor in human lung adenocarcinoma

Recombinant human erythropoietins (rHuEPOs) are used to treat cancer-related anemia. Recent preclinical studies and clinical trials, however, have raised concerns about the potential tumor-promoting effects of these drugs. Because the clinical significance of erythropoietin receptor (EPOR) signaling...

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Veröffentlicht in:	PloS one 2013-10, Vol.8 (10), p.e77459
Hauptverfasser:	Rózsás, Anita, Berta, Judit, Rojkó, Lívia, Horváth, László Z, Keszthelyi, Magdolna, Kenessey, István, László, Viktória, Berger, Walter, Grusch, Michael, Hoda, Mir Alireza, Török, Szilvia, Klepetko, Walter, Rényi-Vámos, Ferenc, Hegedűs, Balázs, Döme, Balázs, Tóvári, József
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Adenocarcinoma - genetics Adenocarcinoma - pathology Adenocarcinoma of Lung Anemia Angiogenesis Animals Apoptosis Biology Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Biotechnology Bronchoscopy Cancer Cancer research Cancer therapies Cell growth Cell Line, Tumor Cell proliferation Cell Proliferation - drug effects Chemotherapy Clinical trials Deoxycytidine - analogs & derivatives Deoxycytidine - pharmacology Drugs Endothelial cells Engineering and Technology Erythropoietin Female Gemcitabine Gene Expression Regulation, Neoplastic - drug effects Humans Hypoxia Immunoglobulins In vivo methods and tests Internal medicine Lung cancer Lung diseases Lung Neoplasms - genetics Lung Neoplasms - pathology Male Malignancy Medical Engineering Medical prognosis Medical research Medicinteknik Metastasis Mice Mice, SCID Middle Aged mRNA Multivariate Analysis Non-small cell lung cancer Non-small cell lung carcinoma Oncology Pathology Patients Polymerase chain reaction Prognosis Receptors, Erythropoietin - genetics Receptors, Erythropoietin - metabolism Recombinant Proteins - pharmacology RNA Studies Surgery Teknik Thoracic surgery Tumors Uridine Xenograft Model Antitumor Assays Xenografts Xenotransplantation
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