Identification of a STAT5 target gene, Dpf3, provides novel insights in chronic lymphocytic leukemia

STAT5 controls essential cellular functions and is encoded by two genes, Stat5a and Stat5b. To provide insight to the mechanisms linking hematologic malignancy to STAT5 activation/regulation of target genes, we identified STAT5 target genes and focused on Dpf3 gene, which encodes for an epigenetic f...

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Veröffentlicht in:	PloS one 2013-10, Vol.8 (10), p.e76155
Hauptverfasser:	Theodorou, Marina, Speletas, Matthaios, Mamara, Antigoni, Papachristopoulou, Georgia, Lazou, Vassiliki, Scorilas, Andreas, Katsantoni, Eleni
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis B cells Base Sequence Binding Biochemistry Biomedical research Cancer Cell activation Cell Line, Tumor Chromatin Immunoprecipitation Chronic lymphatic leukemia Chronic lymphocytic leukemia Cloning Computer networks Cytokines DNA-Binding Proteins - genetics Down-Regulation - drug effects Down-Regulation - genetics Epigenetic inheritance Gene expression Gene Expression Regulation, Leukemic - drug effects Gene Library Gene regulation Genes Genetic aspects Genome, Human - genetics Granulocytes HEK293 Cells Hematology Humans Identification Immunology Interleukin 3 Interleukin-3 - pharmacology Leukemia Leukemia, Lymphocytic, Chronic, B-Cell - genetics Leukocytes (granulocytic) Lymphatic leukemia Lymphocytes B Malignancy Mice Molecular biology Myeloid cells Oncology Patients Physiology Promoter Regions, Genetic - genetics Protein Binding - drug effects Protein Binding - genetics Proteins RNA, Messenger - genetics RNA, Messenger - metabolism Stat5 protein STAT5 Transcription Factor - metabolism Stimulation Target recognition Transcription Transcription activation Transcription factors Transcription Factors - genetics Tumor Suppressor Proteins - metabolism
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