The ESX-3 secretion system is necessary for iron and zinc homeostasis in Mycobacterium tuberculosis
ESX-3 is one of the five type VII secretion systems encoded by the Mycobacterium tuberculosis genome. We recently showed the essentiality of ESX-3 for M. tuberculosis viability and proposed its involvement in iron and zinc metabolism. In this study we confirmed the role of ESX-3 in iron uptake and i...
Gespeichert in:
| Veröffentlicht in: | PloS one 2013-10, Vol.8 (10), p.e78351 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 10 |
| container_start_page | e78351 |
| container_title | PloS one |
| container_volume | 8 |
| creator | Serafini, Agnese Pisu, Davide Palù, Giorgio Rodriguez, G Marcela Manganelli, Riccardo |
| description | ESX-3 is one of the five type VII secretion systems encoded by the Mycobacterium tuberculosis genome. We recently showed the essentiality of ESX-3 for M. tuberculosis viability and proposed its involvement in iron and zinc metabolism. In this study we confirmed the role of ESX-3 in iron uptake and its involvement in the adaptation to low zinc environment in M. tuberculosis. Moreover, we unveiled functional differences between the ESX-3 roles in M. tuberculosis and M. smegmatis showing that in the latter ESX-3 is only involved in the adaptation to iron and not to zinc restriction. Finally, we also showed that in M. tuberculosis this secretion system is essential for iron and zinc homeostasis not only in conditions in which the concentrations of these metals are limiting but also in metal sufficient conditions. |
| doi_str_mv | 10.1371/journal.pone.0078351 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_plos_</sourceid><recordid>TN_cdi_plos_journals_1441864753</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_b23dea5938134925a0c45ce9b9e34318</doaj_id><sourcerecordid>3098690291</sourcerecordid><originalsourceid>FETCH-LOGICAL-c526t-14f6b11ec0adba95c94e1e725dc6aa4be155f648230745c011d8119fd70238ae3</originalsourceid><addsrcrecordid>eNp1Uk1v1DAQjRAVLYV_gMAS5ywefyT2BQlVbalU1ANF4mY5zqTrVRIvdoK0_fX1smnVHjjZ8nvz3pvxFMUHoCvgNXzZhDmOtl9tw4grSmvFJbwqTkBzVlaM8tfP7sfF25Q2lEququpNccwESKmVPCnc7RrJ-c_fJScJXcTJh5GkXZpwID6RER2mZOOOdCESHzNox5bc-9GRdRgwpMmmzPMj-bFzobFuwujngUxzg9HNfcjou-Kos33C98t5Wvy6OL89-15e31xenX27Lp1k1VSC6KoGAB21bWO1dFogYM1k6yprRYM5c1cJxTithXQUoFUAumtryriyyE-LTwfdbbY1y3ySASFAVaKWPDOuDow22I3ZRj_k1kyw3vx7CPHO2Dh516NpGG_RSs0VcKGZtNRlU9SNRi44qKz1dXGbmwFbh-MUbf9C9CUy-rW5C38Nr3XuYh_m8yIQw58Z0_SfyOLAcjGkFLF7cgBq9ovwWGX2i2CWRchlH5-neyp6_Hn-AN0DsnQ</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1441864753</pqid></control><display><type>article</type><title>The ESX-3 secretion system is necessary for iron and zinc homeostasis in Mycobacterium tuberculosis</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Public Library of Science (PLoS) Journals Open Access</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><creator>Serafini, Agnese ; Pisu, Davide ; Palù, Giorgio ; Rodriguez, G Marcela ; Manganelli, Riccardo</creator><contributor>Delogu, Giovanni</contributor><creatorcontrib>Serafini, Agnese ; Pisu, Davide ; Palù, Giorgio ; Rodriguez, G Marcela ; Manganelli, Riccardo ; Delogu, Giovanni</creatorcontrib><description>ESX-3 is one of the five type VII secretion systems encoded by the Mycobacterium tuberculosis genome. We recently showed the essentiality of ESX-3 for M. tuberculosis viability and proposed its involvement in iron and zinc metabolism. In this study we confirmed the role of ESX-3 in iron uptake and its involvement in the adaptation to low zinc environment in M. tuberculosis. Moreover, we unveiled functional differences between the ESX-3 roles in M. tuberculosis and M. smegmatis showing that in the latter ESX-3 is only involved in the adaptation to iron and not to zinc restriction. Finally, we also showed that in M. tuberculosis this secretion system is essential for iron and zinc homeostasis not only in conditions in which the concentrations of these metals are limiting but also in metal sufficient conditions.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0078351</identifier><identifier>PMID: 24155985</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adaptation ; Bacteria ; Bacterial Proteins - metabolism ; Bacterial Secretion Systems - drug effects ; Cell Line ; Cell Wall - drug effects ; Cell Wall - metabolism ; Gene Expression Regulation, Bacterial - drug effects ; Genes, Bacterial - genetics ; Genomes ; Heavy metals ; Hemin - pharmacology ; Homeostasis ; Homeostasis - drug effects ; Humans ; Intracellular Space - drug effects ; Intracellular Space - metabolism ; Iron ; Iron - metabolism ; Macrophages - drug effects ; Macrophages - metabolism ; Macrophages - microbiology ; Medicine ; Metabolism ; Metal concentrations ; Mutation - genetics ; Mycobacterium smegmatis ; Mycobacterium smegmatis - drug effects ; Mycobacterium smegmatis - metabolism ; Mycobacterium tuberculosis ; Mycobacterium tuberculosis - drug effects ; Mycobacterium tuberculosis - genetics ; Mycobacterium tuberculosis - growth & development ; Mycobacterium tuberculosis - metabolism ; Oxazoles - metabolism ; Pathogens ; Permeability - drug effects ; Proteins ; Secretion ; Streptococcus infections ; Streptonigrin - pharmacology ; Transcription, Genetic - drug effects ; Tuberculosis ; Viability ; Zinc ; Zinc - metabolism</subject><ispartof>PloS one, 2013-10, Vol.8 (10), p.e78351</ispartof><rights>2013 Serafini et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2013 Serafini et al 2013 Serafini et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c526t-14f6b11ec0adba95c94e1e725dc6aa4be155f648230745c011d8119fd70238ae3</citedby><cites>FETCH-LOGICAL-c526t-14f6b11ec0adba95c94e1e725dc6aa4be155f648230745c011d8119fd70238ae3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3796483/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3796483/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24155985$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Delogu, Giovanni</contributor><creatorcontrib>Serafini, Agnese</creatorcontrib><creatorcontrib>Pisu, Davide</creatorcontrib><creatorcontrib>Palù, Giorgio</creatorcontrib><creatorcontrib>Rodriguez, G Marcela</creatorcontrib><creatorcontrib>Manganelli, Riccardo</creatorcontrib><title>The ESX-3 secretion system is necessary for iron and zinc homeostasis in Mycobacterium tuberculosis</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>ESX-3 is one of the five type VII secretion systems encoded by the Mycobacterium tuberculosis genome. We recently showed the essentiality of ESX-3 for M. tuberculosis viability and proposed its involvement in iron and zinc metabolism. In this study we confirmed the role of ESX-3 in iron uptake and its involvement in the adaptation to low zinc environment in M. tuberculosis. Moreover, we unveiled functional differences between the ESX-3 roles in M. tuberculosis and M. smegmatis showing that in the latter ESX-3 is only involved in the adaptation to iron and not to zinc restriction. Finally, we also showed that in M. tuberculosis this secretion system is essential for iron and zinc homeostasis not only in conditions in which the concentrations of these metals are limiting but also in metal sufficient conditions.</description><subject>Adaptation</subject><subject>Bacteria</subject><subject>Bacterial Proteins - metabolism</subject><subject>Bacterial Secretion Systems - drug effects</subject><subject>Cell Line</subject><subject>Cell Wall - drug effects</subject><subject>Cell Wall - metabolism</subject><subject>Gene Expression Regulation, Bacterial - drug effects</subject><subject>Genes, Bacterial - genetics</subject><subject>Genomes</subject><subject>Heavy metals</subject><subject>Hemin - pharmacology</subject><subject>Homeostasis</subject><subject>Homeostasis - drug effects</subject><subject>Humans</subject><subject>Intracellular Space - drug effects</subject><subject>Intracellular Space - metabolism</subject><subject>Iron</subject><subject>Iron - metabolism</subject><subject>Macrophages - drug effects</subject><subject>Macrophages - metabolism</subject><subject>Macrophages - microbiology</subject><subject>Medicine</subject><subject>Metabolism</subject><subject>Metal concentrations</subject><subject>Mutation - genetics</subject><subject>Mycobacterium smegmatis</subject><subject>Mycobacterium smegmatis - drug effects</subject><subject>Mycobacterium smegmatis - metabolism</subject><subject>Mycobacterium tuberculosis</subject><subject>Mycobacterium tuberculosis - drug effects</subject><subject>Mycobacterium tuberculosis - genetics</subject><subject>Mycobacterium tuberculosis - growth & development</subject><subject>Mycobacterium tuberculosis - metabolism</subject><subject>Oxazoles - metabolism</subject><subject>Pathogens</subject><subject>Permeability - drug effects</subject><subject>Proteins</subject><subject>Secretion</subject><subject>Streptococcus infections</subject><subject>Streptonigrin - pharmacology</subject><subject>Transcription, Genetic - drug effects</subject><subject>Tuberculosis</subject><subject>Viability</subject><subject>Zinc</subject><subject>Zinc - metabolism</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNp1Uk1v1DAQjRAVLYV_gMAS5ywefyT2BQlVbalU1ANF4mY5zqTrVRIvdoK0_fX1smnVHjjZ8nvz3pvxFMUHoCvgNXzZhDmOtl9tw4grSmvFJbwqTkBzVlaM8tfP7sfF25Q2lEququpNccwESKmVPCnc7RrJ-c_fJScJXcTJh5GkXZpwID6RER2mZOOOdCESHzNox5bc-9GRdRgwpMmmzPMj-bFzobFuwujngUxzg9HNfcjou-Kos33C98t5Wvy6OL89-15e31xenX27Lp1k1VSC6KoGAB21bWO1dFogYM1k6yprRYM5c1cJxTithXQUoFUAumtryriyyE-LTwfdbbY1y3ySASFAVaKWPDOuDow22I3ZRj_k1kyw3vx7CPHO2Dh516NpGG_RSs0VcKGZtNRlU9SNRi44qKz1dXGbmwFbh-MUbf9C9CUy-rW5C38Nr3XuYh_m8yIQw58Z0_SfyOLAcjGkFLF7cgBq9ovwWGX2i2CWRchlH5-neyp6_Hn-AN0DsnQ</recordid><startdate>20131014</startdate><enddate>20131014</enddate><creator>Serafini, Agnese</creator><creator>Pisu, Davide</creator><creator>Palù, Giorgio</creator><creator>Rodriguez, G Marcela</creator><creator>Manganelli, Riccardo</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20131014</creationdate><title>The ESX-3 secretion system is necessary for iron and zinc homeostasis in Mycobacterium tuberculosis</title><author>Serafini, Agnese ; Pisu, Davide ; Palù, Giorgio ; Rodriguez, G Marcela ; Manganelli, Riccardo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c526t-14f6b11ec0adba95c94e1e725dc6aa4be155f648230745c011d8119fd70238ae3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adaptation</topic><topic>Bacteria</topic><topic>Bacterial Proteins - metabolism</topic><topic>Bacterial Secretion Systems - drug effects</topic><topic>Cell Line</topic><topic>Cell Wall - drug effects</topic><topic>Cell Wall - metabolism</topic><topic>Gene Expression Regulation, Bacterial - drug effects</topic><topic>Genes, Bacterial - genetics</topic><topic>Genomes</topic><topic>Heavy metals</topic><topic>Hemin - pharmacology</topic><topic>Homeostasis</topic><topic>Homeostasis - drug effects</topic><topic>Humans</topic><topic>Intracellular Space - drug effects</topic><topic>Intracellular Space - metabolism</topic><topic>Iron</topic><topic>Iron - metabolism</topic><topic>Macrophages - drug effects</topic><topic>Macrophages - metabolism</topic><topic>Macrophages - microbiology</topic><topic>Medicine</topic><topic>Metabolism</topic><topic>Metal concentrations</topic><topic>Mutation - genetics</topic><topic>Mycobacterium smegmatis</topic><topic>Mycobacterium smegmatis - drug effects</topic><topic>Mycobacterium smegmatis - metabolism</topic><topic>Mycobacterium tuberculosis</topic><topic>Mycobacterium tuberculosis - drug effects</topic><topic>Mycobacterium tuberculosis - genetics</topic><topic>Mycobacterium tuberculosis - growth & development</topic><topic>Mycobacterium tuberculosis - metabolism</topic><topic>Oxazoles - metabolism</topic><topic>Pathogens</topic><topic>Permeability - drug effects</topic><topic>Proteins</topic><topic>Secretion</topic><topic>Streptococcus infections</topic><topic>Streptonigrin - pharmacology</topic><topic>Transcription, Genetic - drug effects</topic><topic>Tuberculosis</topic><topic>Viability</topic><topic>Zinc</topic><topic>Zinc - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Serafini, Agnese</creatorcontrib><creatorcontrib>Pisu, Davide</creatorcontrib><creatorcontrib>Palù, Giorgio</creatorcontrib><creatorcontrib>Rodriguez, G Marcela</creatorcontrib><creatorcontrib>Manganelli, Riccardo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Serafini, Agnese</au><au>Pisu, Davide</au><au>Palù, Giorgio</au><au>Rodriguez, G Marcela</au><au>Manganelli, Riccardo</au><au>Delogu, Giovanni</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The ESX-3 secretion system is necessary for iron and zinc homeostasis in Mycobacterium tuberculosis</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2013-10-14</date><risdate>2013</risdate><volume>8</volume><issue>10</issue><spage>e78351</spage><pages>e78351-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>ESX-3 is one of the five type VII secretion systems encoded by the Mycobacterium tuberculosis genome. We recently showed the essentiality of ESX-3 for M. tuberculosis viability and proposed its involvement in iron and zinc metabolism. In this study we confirmed the role of ESX-3 in iron uptake and its involvement in the adaptation to low zinc environment in M. tuberculosis. Moreover, we unveiled functional differences between the ESX-3 roles in M. tuberculosis and M. smegmatis showing that in the latter ESX-3 is only involved in the adaptation to iron and not to zinc restriction. Finally, we also showed that in M. tuberculosis this secretion system is essential for iron and zinc homeostasis not only in conditions in which the concentrations of these metals are limiting but also in metal sufficient conditions.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>24155985</pmid><doi>10.1371/journal.pone.0078351</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2013-10, Vol.8 (10), p.e78351 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1441864753 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Public Library of Science (PLoS) Journals Open Access; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adaptation Bacteria Bacterial Proteins - metabolism Bacterial Secretion Systems - drug effects Cell Line Cell Wall - drug effects Cell Wall - metabolism Gene Expression Regulation, Bacterial - drug effects Genes, Bacterial - genetics Genomes Heavy metals Hemin - pharmacology Homeostasis Homeostasis - drug effects Humans Intracellular Space - drug effects Intracellular Space - metabolism Iron Iron - metabolism Macrophages - drug effects Macrophages - metabolism Macrophages - microbiology Medicine Metabolism Metal concentrations Mutation - genetics Mycobacterium smegmatis Mycobacterium smegmatis - drug effects Mycobacterium smegmatis - metabolism Mycobacterium tuberculosis Mycobacterium tuberculosis - drug effects Mycobacterium tuberculosis - genetics Mycobacterium tuberculosis - growth & development Mycobacterium tuberculosis - metabolism Oxazoles - metabolism Pathogens Permeability - drug effects Proteins Secretion Streptococcus infections Streptonigrin - pharmacology Transcription, Genetic - drug effects Tuberculosis Viability Zinc Zinc - metabolism |
| title | The ESX-3 secretion system is necessary for iron and zinc homeostasis in Mycobacterium tuberculosis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-19T01%3A54%3A09IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20ESX-3%20secretion%20system%20is%20necessary%20for%20iron%20and%20zinc%20homeostasis%20in%20Mycobacterium%20tuberculosis&rft.jtitle=PloS%20one&rft.au=Serafini,%20Agnese&rft.date=2013-10-14&rft.volume=8&rft.issue=10&rft.spage=e78351&rft.pages=e78351-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0078351&rft_dat=%3Cproquest_plos_%3E3098690291%3C/proquest_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1441864753&rft_id=info:pmid/24155985&rft_doaj_id=oai_doaj_org_article_b23dea5938134925a0c45ce9b9e34318&rfr_iscdi=true |