Prevalence, hemodynamics, and cytokine profile of effusive-constrictive pericarditis in patients with tuberculous pericardial effusion
Effusive constrictive pericarditis (ECP) is visceral constriction in conjunction with compressive pericardial effusion. The prevalence of proven tuberculous ECP is unknown. Whilst ECP is distinguished from effusive disease on hemodynamic grounds, it is unknown whether effusive-constrictive physiolog...
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| creator | Ntsekhe, Mpiko Matthews, Kerryn Syed, Faisal F Deffur, Armin Badri, Motasim Commerford, Patrick J Gersh, Bernard J Wilkinson, Katalin A Wilkinson, Robert J Mayosi, Bongani M |
| description | Effusive constrictive pericarditis (ECP) is visceral constriction in conjunction with compressive pericardial effusion. The prevalence of proven tuberculous ECP is unknown. Whilst ECP is distinguished from effusive disease on hemodynamic grounds, it is unknown whether effusive-constrictive physiology has a distinct cytokine profile. We conducted a prospective study of prevalence and cytokine profile of effusive-constrictive disease in patients with tuberculous pericardial effusion.
From July 2006 through July 2009, the prevalence of ECP and serum and pericardial levels of inflammatory cytokines were determined in adults with tuberculous pericardial effusion. The diagnosis of ECP was made by combined pericardiocentesis and cardiac catheterization.
Of 91 patients evaluated, 68 had tuberculous pericarditis. The 36/68 patients (52.9%; 95% confidence interval [CI]: 41.2-65.4) with ECP were younger (29 versus 37 years, P=0.02), had a higher pre-pericardiocentesis right atrial pressure (17.0 versus 10.0 mmHg, P |
| doi_str_mv | 10.1371/journal.pone.0077532 |
| format | Article |
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From July 2006 through July 2009, the prevalence of ECP and serum and pericardial levels of inflammatory cytokines were determined in adults with tuberculous pericardial effusion. The diagnosis of ECP was made by combined pericardiocentesis and cardiac catheterization.
Of 91 patients evaluated, 68 had tuberculous pericarditis. The 36/68 patients (52.9%; 95% confidence interval [CI]: 41.2-65.4) with ECP were younger (29 versus 37 years, P=0.02), had a higher pre-pericardiocentesis right atrial pressure (17.0 versus 10.0 mmHg, P<0.0001), serum concentration of interleukin-10 (IL-10) (38.5 versus 0.2 pg/ml, P<0.001) and transforming growth factor-beta (121.5 versus 29.1 pg/ml, P=0.02), pericardial concentration of IL-10 (84.7 versus 20.4 pg/ml, P=0.006) and interferon-gamma (2,568.0 versus 906.6 pg/ml, P=0.03) than effusive non-constrictive cases. In multivariable regression analysis, right atrial pressure > 15 mmHg (odds ratio [OR] = 48, 95%CI: 8.7-265; P<0.0001) and IL-10 > 200 pg/ml (OR=10, 95%CI: 1.1, 93; P=0.04) were independently associated with ECP.
Effusive-constrictive disease occurs in half of cases of tuberculous pericardial effusion, and is characterized by greater elevation in the pre-pericardiocentesis right atrial pressure and pericardial and serum IL-10 levels compared to patients with effusive non-constrictive tuberculous pericarditis.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0077532</identifier><identifier>PMID: 24155965</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Adults ; Africa - epidemiology ; Cardiac patients ; Care and treatment ; Catheterization ; Catheters ; Circulatory system ; Confidence intervals ; Constrictions ; Cytokines ; Cytokines - blood ; Effusion ; Female ; Growth factors ; Heart ; Heart diseases ; Hemodynamics ; HIV ; Hospitals ; Human immunodeficiency virus ; Humans ; Infections ; Infectious diseases ; Inflammation ; Interferon ; Interleukin ; Interleukin 10 ; Interleukins ; Intubation ; Logistic Models ; Male ; Medical research ; Medicine ; Multivariate Analysis ; Mycobacterium tuberculosis ; Patients ; Pericardial Effusion - blood ; Pericardial Effusion - complications ; Pericardial Effusion - epidemiology ; Pericardial Effusion - physiopathology ; Pericarditis ; Pericarditis, Constrictive - blood ; Pericarditis, Constrictive - complications ; Pericarditis, Constrictive - epidemiology ; Pericarditis, Constrictive - physiopathology ; Physiological aspects ; Pressure ; Prevalence ; Prevalence studies (Epidemiology) ; Regression analysis ; Statistical analysis ; Transforming growth factor-b ; Tuberculosis ; Tuberculosis - blood ; Tuberculosis - complications ; Tuberculosis - epidemiology ; Tuberculosis - physiopathology ; Tumor necrosis factor-TNF ; γ-Interferon</subject><ispartof>PloS one, 2013-10, Vol.8 (10), p.e77532-e77532</ispartof><rights>COPYRIGHT 2013 Public Library of Science</rights><rights>2013 Ntsekhe et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2013 Ntsekhe et al 2013 Ntsekhe et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c585t-1474d8ba1253e838935f5024dd9440668ed6aa2d5627c7d252ca398bf0b17e4e3</citedby><cites>FETCH-LOGICAL-c585t-1474d8ba1253e838935f5024dd9440668ed6aa2d5627c7d252ca398bf0b17e4e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3796485/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3796485/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79569,79570</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24155965$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ntsekhe, Mpiko</creatorcontrib><creatorcontrib>Matthews, Kerryn</creatorcontrib><creatorcontrib>Syed, Faisal F</creatorcontrib><creatorcontrib>Deffur, Armin</creatorcontrib><creatorcontrib>Badri, Motasim</creatorcontrib><creatorcontrib>Commerford, Patrick J</creatorcontrib><creatorcontrib>Gersh, Bernard J</creatorcontrib><creatorcontrib>Wilkinson, Katalin A</creatorcontrib><creatorcontrib>Wilkinson, Robert J</creatorcontrib><creatorcontrib>Mayosi, Bongani M</creatorcontrib><title>Prevalence, hemodynamics, and cytokine profile of effusive-constrictive pericarditis in patients with tuberculous pericardial effusion</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Effusive constrictive pericarditis (ECP) is visceral constriction in conjunction with compressive pericardial effusion. The prevalence of proven tuberculous ECP is unknown. Whilst ECP is distinguished from effusive disease on hemodynamic grounds, it is unknown whether effusive-constrictive physiology has a distinct cytokine profile. We conducted a prospective study of prevalence and cytokine profile of effusive-constrictive disease in patients with tuberculous pericardial effusion.
From July 2006 through July 2009, the prevalence of ECP and serum and pericardial levels of inflammatory cytokines were determined in adults with tuberculous pericardial effusion. The diagnosis of ECP was made by combined pericardiocentesis and cardiac catheterization.
Of 91 patients evaluated, 68 had tuberculous pericarditis. The 36/68 patients (52.9%; 95% confidence interval [CI]: 41.2-65.4) with ECP were younger (29 versus 37 years, P=0.02), had a higher pre-pericardiocentesis right atrial pressure (17.0 versus 10.0 mmHg, P<0.0001), serum concentration of interleukin-10 (IL-10) (38.5 versus 0.2 pg/ml, P<0.001) and transforming growth factor-beta (121.5 versus 29.1 pg/ml, P=0.02), pericardial concentration of IL-10 (84.7 versus 20.4 pg/ml, P=0.006) and interferon-gamma (2,568.0 versus 906.6 pg/ml, P=0.03) than effusive non-constrictive cases. In multivariable regression analysis, right atrial pressure > 15 mmHg (odds ratio [OR] = 48, 95%CI: 8.7-265; P<0.0001) and IL-10 > 200 pg/ml (OR=10, 95%CI: 1.1, 93; P=0.04) were independently associated with ECP.
Effusive-constrictive disease occurs in half of cases of tuberculous pericardial effusion, and is characterized by greater elevation in the pre-pericardiocentesis right atrial pressure and pericardial and serum IL-10 levels compared to patients with effusive non-constrictive tuberculous pericarditis.</description><subject>Adult</subject><subject>Adults</subject><subject>Africa - epidemiology</subject><subject>Cardiac patients</subject><subject>Care and treatment</subject><subject>Catheterization</subject><subject>Catheters</subject><subject>Circulatory system</subject><subject>Confidence intervals</subject><subject>Constrictions</subject><subject>Cytokines</subject><subject>Cytokines - blood</subject><subject>Effusion</subject><subject>Female</subject><subject>Growth factors</subject><subject>Heart</subject><subject>Heart diseases</subject><subject>Hemodynamics</subject><subject>HIV</subject><subject>Hospitals</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Inflammation</subject><subject>Interferon</subject><subject>Interleukin</subject><subject>Interleukin 10</subject><subject>Interleukins</subject><subject>Intubation</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Multivariate Analysis</subject><subject>Mycobacterium tuberculosis</subject><subject>Patients</subject><subject>Pericardial Effusion - blood</subject><subject>Pericardial Effusion - complications</subject><subject>Pericardial Effusion - epidemiology</subject><subject>Pericardial Effusion - physiopathology</subject><subject>Pericarditis</subject><subject>Pericarditis, Constrictive - blood</subject><subject>Pericarditis, Constrictive - complications</subject><subject>Pericarditis, Constrictive - epidemiology</subject><subject>Pericarditis, Constrictive - physiopathology</subject><subject>Physiological aspects</subject><subject>Pressure</subject><subject>Prevalence</subject><subject>Prevalence studies (Epidemiology)</subject><subject>Regression analysis</subject><subject>Statistical analysis</subject><subject>Transforming growth factor-b</subject><subject>Tuberculosis</subject><subject>Tuberculosis - blood</subject><subject>Tuberculosis - complications</subject><subject>Tuberculosis - epidemiology</subject><subject>Tuberculosis - physiopathology</subject><subject>Tumor necrosis factor-TNF</subject><subject>γ-Interferon</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNptkstuEzEUhkcIREvhDRCMhIRYNGF8n9kgVRWXSpVgAWvLY59JHBw72J6gvADPjUOmJUGsfGx_5z_XqnqOmjkiAr1dhTF65eab4GHeNEIwgh9U56gjeMZxQx4e2WfVk5RWTcNIy_nj6gxTxFjH2Xn160uErXLgNVzWS1gHs_NqbXW6rJU3td7l8N16qDcxDNZBHYYahmFMdgszHXzK0epcLvUGiqWisdmm2vp6o7IFn1P90-Zlncceoh5dGNNfUrlJK_in1aNBuQTPpvOi-vbh_dfrT7Pbzx9vrq9uZ5q1LM8QFdS0vUKYEWhJ2xE2sAZTYzpKG85bMFwpbBjHQguDGdaKdG0_ND0SQIFcVC8PuhsXkpxamCSiFLWcCiIKcXMgTFAruYl2reJOBmXln4cQF1LFbLUD2fQY4870DLWC6g66HuEOOMacAVCjita7KdrYr8Ho0o-o3Ino6Y-3S7kIW0lEx2nLisCbSSCGHyOkLNc2aXBOeSit3OfNOoQbhAv66h_0_9VN1KLMXFo_hBJX70XlFRUtFpixPfX6iFqCcnmZghtzmVQ6BekB1DGkFGG4rw01cr-ld0nI_ZbKaUuL24vjvtw73a0l-Q1hJObk</recordid><startdate>20131014</startdate><enddate>20131014</enddate><creator>Ntsekhe, Mpiko</creator><creator>Matthews, Kerryn</creator><creator>Syed, Faisal F</creator><creator>Deffur, Armin</creator><creator>Badri, Motasim</creator><creator>Commerford, Patrick J</creator><creator>Gersh, Bernard J</creator><creator>Wilkinson, Katalin A</creator><creator>Wilkinson, Robert J</creator><creator>Mayosi, Bongani M</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PIMPY</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQGLB</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20131014</creationdate><title>Prevalence, hemodynamics, and cytokine profile of effusive-constrictive pericarditis in patients with tuberculous pericardial effusion</title><author>Ntsekhe, Mpiko ; Matthews, Kerryn ; Syed, Faisal F ; Deffur, Armin ; Badri, Motasim ; Commerford, Patrick J ; Gersh, Bernard J ; Wilkinson, Katalin A ; Wilkinson, Robert J ; Mayosi, Bongani M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c585t-1474d8ba1253e838935f5024dd9440668ed6aa2d5627c7d252ca398bf0b17e4e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Adults</topic><topic>Africa - epidemiology</topic><topic>Cardiac patients</topic><topic>Care and treatment</topic><topic>Catheterization</topic><topic>Catheters</topic><topic>Circulatory system</topic><topic>Confidence intervals</topic><topic>Constrictions</topic><topic>Cytokines</topic><topic>Cytokines - blood</topic><topic>Effusion</topic><topic>Female</topic><topic>Growth factors</topic><topic>Heart</topic><topic>Heart diseases</topic><topic>Hemodynamics</topic><topic>HIV</topic><topic>Hospitals</topic><topic>Human immunodeficiency virus</topic><topic>Humans</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Inflammation</topic><topic>Interferon</topic><topic>Interleukin</topic><topic>Interleukin 10</topic><topic>Interleukins</topic><topic>Intubation</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Medical research</topic><topic>Medicine</topic><topic>Multivariate Analysis</topic><topic>Mycobacterium tuberculosis</topic><topic>Patients</topic><topic>Pericardial Effusion - blood</topic><topic>Pericardial Effusion - complications</topic><topic>Pericardial Effusion - epidemiology</topic><topic>Pericardial Effusion - physiopathology</topic><topic>Pericarditis</topic><topic>Pericarditis, Constrictive - blood</topic><topic>Pericarditis, Constrictive - complications</topic><topic>Pericarditis, Constrictive - epidemiology</topic><topic>Pericarditis, Constrictive - physiopathology</topic><topic>Physiological aspects</topic><topic>Pressure</topic><topic>Prevalence</topic><topic>Prevalence studies (Epidemiology)</topic><topic>Regression analysis</topic><topic>Statistical analysis</topic><topic>Transforming growth factor-b</topic><topic>Tuberculosis</topic><topic>Tuberculosis - blood</topic><topic>Tuberculosis - complications</topic><topic>Tuberculosis - epidemiology</topic><topic>Tuberculosis - physiopathology</topic><topic>Tumor necrosis factor-TNF</topic><topic>γ-Interferon</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ntsekhe, Mpiko</creatorcontrib><creatorcontrib>Matthews, Kerryn</creatorcontrib><creatorcontrib>Syed, Faisal F</creatorcontrib><creatorcontrib>Deffur, Armin</creatorcontrib><creatorcontrib>Badri, Motasim</creatorcontrib><creatorcontrib>Commerford, Patrick J</creatorcontrib><creatorcontrib>Gersh, Bernard J</creatorcontrib><creatorcontrib>Wilkinson, Katalin A</creatorcontrib><creatorcontrib>Wilkinson, Robert J</creatorcontrib><creatorcontrib>Mayosi, Bongani M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ntsekhe, Mpiko</au><au>Matthews, Kerryn</au><au>Syed, Faisal F</au><au>Deffur, Armin</au><au>Badri, Motasim</au><au>Commerford, Patrick J</au><au>Gersh, Bernard J</au><au>Wilkinson, Katalin A</au><au>Wilkinson, Robert J</au><au>Mayosi, Bongani M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevalence, hemodynamics, and cytokine profile of effusive-constrictive pericarditis in patients with tuberculous pericardial effusion</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2013-10-14</date><risdate>2013</risdate><volume>8</volume><issue>10</issue><spage>e77532</spage><epage>e77532</epage><pages>e77532-e77532</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Effusive constrictive pericarditis (ECP) is visceral constriction in conjunction with compressive pericardial effusion. The prevalence of proven tuberculous ECP is unknown. Whilst ECP is distinguished from effusive disease on hemodynamic grounds, it is unknown whether effusive-constrictive physiology has a distinct cytokine profile. We conducted a prospective study of prevalence and cytokine profile of effusive-constrictive disease in patients with tuberculous pericardial effusion.
From July 2006 through July 2009, the prevalence of ECP and serum and pericardial levels of inflammatory cytokines were determined in adults with tuberculous pericardial effusion. The diagnosis of ECP was made by combined pericardiocentesis and cardiac catheterization.
Of 91 patients evaluated, 68 had tuberculous pericarditis. The 36/68 patients (52.9%; 95% confidence interval [CI]: 41.2-65.4) with ECP were younger (29 versus 37 years, P=0.02), had a higher pre-pericardiocentesis right atrial pressure (17.0 versus 10.0 mmHg, P<0.0001), serum concentration of interleukin-10 (IL-10) (38.5 versus 0.2 pg/ml, P<0.001) and transforming growth factor-beta (121.5 versus 29.1 pg/ml, P=0.02), pericardial concentration of IL-10 (84.7 versus 20.4 pg/ml, P=0.006) and interferon-gamma (2,568.0 versus 906.6 pg/ml, P=0.03) than effusive non-constrictive cases. In multivariable regression analysis, right atrial pressure > 15 mmHg (odds ratio [OR] = 48, 95%CI: 8.7-265; P<0.0001) and IL-10 > 200 pg/ml (OR=10, 95%CI: 1.1, 93; P=0.04) were independently associated with ECP.
Effusive-constrictive disease occurs in half of cases of tuberculous pericardial effusion, and is characterized by greater elevation in the pre-pericardiocentesis right atrial pressure and pericardial and serum IL-10 levels compared to patients with effusive non-constrictive tuberculous pericarditis.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>24155965</pmid><doi>10.1371/journal.pone.0077532</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2013-10, Vol.8 (10), p.e77532-e77532 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1441864737 |
| source | Public Library of Science (PLoS) Journals Open Access; MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adult Adults Africa - epidemiology Cardiac patients Care and treatment Catheterization Catheters Circulatory system Confidence intervals Constrictions Cytokines Cytokines - blood Effusion Female Growth factors Heart Heart diseases Hemodynamics HIV Hospitals Human immunodeficiency virus Humans Infections Infectious diseases Inflammation Interferon Interleukin Interleukin 10 Interleukins Intubation Logistic Models Male Medical research Medicine Multivariate Analysis Mycobacterium tuberculosis Patients Pericardial Effusion - blood Pericardial Effusion - complications Pericardial Effusion - epidemiology Pericardial Effusion - physiopathology Pericarditis Pericarditis, Constrictive - blood Pericarditis, Constrictive - complications Pericarditis, Constrictive - epidemiology Pericarditis, Constrictive - physiopathology Physiological aspects Pressure Prevalence Prevalence studies (Epidemiology) Regression analysis Statistical analysis Transforming growth factor-b Tuberculosis Tuberculosis - blood Tuberculosis - complications Tuberculosis - epidemiology Tuberculosis - physiopathology Tumor necrosis factor-TNF γ-Interferon |
| title | Prevalence, hemodynamics, and cytokine profile of effusive-constrictive pericarditis in patients with tuberculous pericardial effusion |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-21T21%3A22%3A54IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Prevalence,%20hemodynamics,%20and%20cytokine%20profile%20of%20effusive-constrictive%20pericarditis%20in%20patients%20with%20tuberculous%20pericardial%20effusion&rft.jtitle=PloS%20one&rft.au=Ntsekhe,%20Mpiko&rft.date=2013-10-14&rft.volume=8&rft.issue=10&rft.spage=e77532&rft.epage=e77532&rft.pages=e77532-e77532&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0077532&rft_dat=%3Cgale_plos_%3EA478272557%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1441864737&rft_id=info:pmid/24155965&rft_galeid=A478272557&rft_doaj_id=oai_doaj_org_article_0b2229db51874c9e9b129e62265ee4da&rfr_iscdi=true |