Overnight resting of PBMC changes functional signatures of antigen specific T- cell responses: impact for immune monitoring within clinical trials

Polyfunctional CD4 or CD8 T cells are proposed to represent a correlate of immune control for persistent viruses as well as for vaccine mediated protection against infection. A well-suited methodology to study complex functional phenotypes of antiviral T cells is the combined staining of intracellul...

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Veröffentlicht in:	PloS one 2013-10, Vol.8 (10), p.e76215-e76215
Hauptverfasser:	Kutscher, Sarah, Dembek, Claudia J, Deckert, Simone, Russo, Carolina, Körber, Nina, Bogner, Johannes R, Geisler, Fabian, Umgelter, Andreas, Neuenhahn, Michael, Albrecht, Julia, Cosma, Antonio, Protzer, Ulrike, Bauer, Tanja
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged AIDS vaccines Antigen-presenting cells Antigen-Presenting Cells - immunology Antigens Antigens - immunology Antiviral agents B cells CD4 antigen CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - virology CD8 antigen CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - virology Cell Survival Chemokines - metabolism Clinical trials Clinical Trials as Topic Cooperation Cryopreservation Cytokines Cytomegalovirus Cytometry Epitopes - immunology Epitopes, T-Lymphocyte - immunology Female Flow cytometry Health aspects Hepatitis Hepatitis B Hepatitis C virus HIV Human immunodeficiency virus Humans Immune response Immunology Infection Inflammation Mediators - metabolism Interleukin 2 Internal medicine Intracellular Intracellular Space - metabolism Lymphocyte Count Lymphocytes Lymphocytes T Male Medical research Middle Aged Monitoring, Immunologic Peripheral blood mononuclear cells Phenotypes Sensitivity Staining Staining and Labeling Standardization T cell receptors T cells Time Factors Tumor necrosis factor-α Vaccines Virology Viruses γ-Interferon
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