MicroRNA-3906 regulates fast muscle differentiation through modulating the target gene homer-1b in zebrafish embryos

A microRNA, termed miR-In300 or miR-3906, suppresses the transcription of myf5 through silencing dickkopf-related protein 3 (dkk3r/dkk3a) during early development when myf5 is highly transcribed, but not at late stages when myf5 transcription is reduced. Moreover, after 24 hpf, when muscle cells are...

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Veröffentlicht in:	PloS one 2013-07, Vol.8 (7), p.e70187-e70187
Hauptverfasser:	Lin, Cheng-Yung, Chen, Jie-Shin, Loo, Moo-Rung, Hsiao, Chung-Ching, Chang, Wen-Yen, Tsai, Huai-Jen
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions - genetics Actin Animals Animals, Genetically Modified Binding Sites - genetics Biology Calcium Calcium (intracellular) Calcium (reticular) Calcium - metabolism Calcium content Calcium homeostasis Cell Differentiation - genetics Cellular biology Danio rerio Defects Differentiation Embryo, Nonmammalian - cytology Embryo, Nonmammalian - embryology Embryo, Nonmammalian - metabolism Embryos Fibrils Gene expression Gene Expression Profiling Gene Expression Regulation, Developmental Gene Knockdown Techniques Gene silencing Homeostasis In Situ Hybridization Kinases Leukemia Medicine MicroRNAs MicroRNAs - genetics MicroRNAs - metabolism Microscopy, Electron, Transmission miRNA Muscle Fibers, Fast-Twitch - cytology Muscle Fibers, Fast-Twitch - metabolism Muscle, Skeletal - cytology Muscle, Skeletal - embryology Muscle, Skeletal - metabolism Muscles Musculoskeletal system Mutation Myogenesis Oligonucleotide Array Sequence Analysis Proteins Reverse Transcriptase Polymerase Chain Reaction Ribonucleic acid RNA Rodents Sarcoplasmic reticulum Sarcoplasmic Reticulum - metabolism Sarcoplasmic Reticulum - ultrastructure Zebrafish Zebrafish - embryology Zebrafish - genetics Zebrafish Proteins - genetics Zebrafish Proteins - metabolism
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