MicroRNA-224 targets SMAD family member 4 to promote cell proliferation and negatively influence patient survival

MicroRNA-224 (miR-224) is frequently over-expressed in liver and colorectal cancers. We and others have previously described the role of miR-224 over-expression in cell proliferation in vitro but we have yet to identify the relevant miR-224 direct target. In this study, we further demonstrated that...

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Veröffentlicht in:	PloS one 2013-07, Vol.8 (7), p.e68744-e68744
Hauptverfasser:	Wang, Yu, Ren, Jianwei, Gao, Yun, Ma, Joel Z I, Toh, Han Chong, Chow, Pierce, Chung, Alexander Y F, Ooi, London L P J, Lee, Caroline G L
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Animals Apoptosis Base Sequence Binding sites Biochemistry Bioinformatics Biology Breast cancer Cancer Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - pathology Cell growth Cell Proliferation Cell survival Cloning Confidence intervals Down-Regulation - genetics Gene expression Gene Expression Regulation, Neoplastic Gene Ontology Genes Genomes Growth factors HCT116 Cells Hep G2 Cells Hospitals Humans Kinases Liver Liver cancer Liver Neoplasms - genetics Liver Neoplasms - pathology Medical research Medicine Mice Mice, Inbred BALB C Mice, Nude MicroRNAs MicroRNAs - genetics MicroRNAs - metabolism miRNA Molecular Sequence Data Overexpression Proteins Ribonucleic acid RNA Smad protein Smad4 protein Smad4 Protein - metabolism Statistical analysis Surgery Survival Survival Analysis Target recognition Tissues Transcription Tumorigenesis
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