Mechanistic insights into the neutralization of cytotoxic abrin by the monoclonal antibody D6F10

Abrin, an A/B toxin obtained from the Abrus precatorius plant is extremely toxic and a potential bio-warfare agent. Till date there is no antidote or vaccine available against this toxin. The only known neutralizing monoclonal antibody against abrin, namely D6F10, has been shown to rescue the toxici...

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Veröffentlicht in:	PloS one 2013-07, Vol.8 (7), p.e70273
Hauptverfasser:	Bagaria, Shradha, Ponnalagu, Devasena, Bisht, Shveta, Karande, Anjali A
Format:	Artikel
Sprache:	eng
Schlagworte:	Abrin - antagonists & inhibitors Abrin - chemistry Abrin - immunology Abrin - toxicity Abrus precatorius Amino Acid Sequence Amino acids Animals Antibodies, Monoclonal - chemistry Antibodies, Monoclonal - immunology Antibodies, Neutralizing - chemistry Antibodies, Neutralizing - immunology Antitoxins - chemistry Antitoxins - immunology Binding Binding Sites Biochemistry Biology Catalytic Domain Cell adhesion Chains Chromatography Confocal microscopy Cytotoxicity E coli Enzymatic activity Epitope Mapping Escherichia coli Humans Immunoglobulins Immunology Inhibition Internalization Medicine Microscopy Mode of action Molecular Docking Simulation Molecular Sequence Data Monoclonal antibodies Neutralization Neutralization Tests Neutralizing Protein Binding - immunology Protein biosynthesis Protein Conformation Protein synthesis Proteins Rabbits Ricin Toxicity Toxins Toxins, Biological - antagonists & inhibitors Toxins, Biological - chemistry Toxins, Biological - immunology Toxins, Biological - toxicity Warfare
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