Prognostic value of radiological response to chemotherapy in patients with osteosarcoma
Chemotherapy is essential to improve the prognosis of the patients with osteosarcoma, and the response to chemotherapy is an important prognostic factor. In this study, the impact of various radiological examinations on overall survival (OS) and event-free survival (EFS) was evaluated. Eighty-two pa...
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| Veröffentlicht in: | PloS one 2013-07, Vol.8 (7), p.e70015-e70015 |
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| creator | Miwa, Shinji Takeuchi, Akihiko Shirai, Toshiharu Taki, Junichi Yamamoto, Norio Nishida, Hideji Hayashi, Katsuhiro Tanzawa, Yoshikazu Kimura, Hiroaki Igarashi, Kentaro Ooi, Akishi Tsuchiya, Hiroyuki |
| description | Chemotherapy is essential to improve the prognosis of the patients with osteosarcoma, and the response to chemotherapy is an important prognostic factor. In this study, the impact of various radiological examinations on overall survival (OS) and event-free survival (EFS) was evaluated.
Eighty-two patients with high-grade osteosarcoma were included in this study, and we evaluated the following factors for prognostic significance: age (≥40 years), gender (male), tumor location (truncal site), metastatic disease, histological response to chemotherapy, radiological response to chemotherapy assessed using X-ray, angiography, CT, MRI, (201)Tl scintigraphy, and (99m)Tc-MIBI scintigraphy ((99m)Tc-MIBI), and combined radiological score (CRS).
Univariate analyses revealed that metastatic disease, histological response, (99m)Tc-MIBI, and CRS were significantly correlated with OS. Multivariate analyses showed that metastatic disease (OS: HR 35.9, P |
| doi_str_mv | 10.1371/journal.pone.0070015 |
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Eighty-two patients with high-grade osteosarcoma were included in this study, and we evaluated the following factors for prognostic significance: age (≥40 years), gender (male), tumor location (truncal site), metastatic disease, histological response to chemotherapy, radiological response to chemotherapy assessed using X-ray, angiography, CT, MRI, (201)Tl scintigraphy, and (99m)Tc-MIBI scintigraphy ((99m)Tc-MIBI), and combined radiological score (CRS).
Univariate analyses revealed that metastatic disease, histological response, (99m)Tc-MIBI, and CRS were significantly correlated with OS. Multivariate analyses showed that metastatic disease (OS: HR 35.9, P<0.001; EFS: HR 17.32, P<0.001) was an independent predictor of OS and EFS. Tumor location (HR 36.1, P = 0.003), histological response (HR 31.1, P = 0.036), and (99m)Tc-MIBI (HR 18.4, P = 0.038) were significant prognostic factors for OS. Moreover, CRS was a marginally significant predictor of OS and EFS.
The chemotherapeutic effects evaluated by (99m)Tc-MIBI and CRS could be considered as prognostic factors in osteosarcoma.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0070015</identifier><identifier>PMID: 23922892</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Angiography ; Biocompatibility ; Bone cancer ; Caffeine ; Chemotherapy ; Clinical outcomes ; Computed tomography ; Correlation analysis ; Disease-Free Survival ; Female ; Humans ; Magnetic resonance imaging ; Male ; Medical imaging ; Medicine ; Metastases ; NMR ; Nuclear magnetic resonance ; Osteosarcoma ; Osteosarcoma - diagnostic imaging ; Osteosarcoma - drug therapy ; Osteosarcoma - mortality ; Patients ; Prognosis ; Quality ; Radionuclide Imaging ; Sarcoma ; Scintigraphy ; Surgery ; Survival ; Technetium Tc 99m Sestamibi ; Treatment Outcome ; Tumors</subject><ispartof>PloS one, 2013-07, Vol.8 (7), p.e70015-e70015</ispartof><rights>2013 Miwa et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2013 Miwa et al 2013 Miwa et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c526t-18e0618f4b9df98ad552a10a01eb64c842d6297856979eabd92b14eb08fcf36e3</citedby><cites>FETCH-LOGICAL-c526t-18e0618f4b9df98ad552a10a01eb64c842d6297856979eabd92b14eb08fcf36e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3726455/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3726455/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2095,2914,23846,27903,27904,53770,53772,79347,79348</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23922892$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Alonso, Marta M.</contributor><creatorcontrib>Miwa, Shinji</creatorcontrib><creatorcontrib>Takeuchi, Akihiko</creatorcontrib><creatorcontrib>Shirai, Toshiharu</creatorcontrib><creatorcontrib>Taki, Junichi</creatorcontrib><creatorcontrib>Yamamoto, Norio</creatorcontrib><creatorcontrib>Nishida, Hideji</creatorcontrib><creatorcontrib>Hayashi, Katsuhiro</creatorcontrib><creatorcontrib>Tanzawa, Yoshikazu</creatorcontrib><creatorcontrib>Kimura, Hiroaki</creatorcontrib><creatorcontrib>Igarashi, Kentaro</creatorcontrib><creatorcontrib>Ooi, Akishi</creatorcontrib><creatorcontrib>Tsuchiya, Hiroyuki</creatorcontrib><title>Prognostic value of radiological response to chemotherapy in patients with osteosarcoma</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Chemotherapy is essential to improve the prognosis of the patients with osteosarcoma, and the response to chemotherapy is an important prognostic factor. In this study, the impact of various radiological examinations on overall survival (OS) and event-free survival (EFS) was evaluated.
Eighty-two patients with high-grade osteosarcoma were included in this study, and we evaluated the following factors for prognostic significance: age (≥40 years), gender (male), tumor location (truncal site), metastatic disease, histological response to chemotherapy, radiological response to chemotherapy assessed using X-ray, angiography, CT, MRI, (201)Tl scintigraphy, and (99m)Tc-MIBI scintigraphy ((99m)Tc-MIBI), and combined radiological score (CRS).
Univariate analyses revealed that metastatic disease, histological response, (99m)Tc-MIBI, and CRS were significantly correlated with OS. Multivariate analyses showed that metastatic disease (OS: HR 35.9, P<0.001; EFS: HR 17.32, P<0.001) was an independent predictor of OS and EFS. Tumor location (HR 36.1, P = 0.003), histological response (HR 31.1, P = 0.036), and (99m)Tc-MIBI (HR 18.4, P = 0.038) were significant prognostic factors for OS. Moreover, CRS was a marginally significant predictor of OS and EFS.
The chemotherapeutic effects evaluated by (99m)Tc-MIBI and CRS could be considered as prognostic factors in osteosarcoma.</description><subject>Adult</subject><subject>Angiography</subject><subject>Biocompatibility</subject><subject>Bone cancer</subject><subject>Caffeine</subject><subject>Chemotherapy</subject><subject>Clinical outcomes</subject><subject>Computed tomography</subject><subject>Correlation analysis</subject><subject>Disease-Free Survival</subject><subject>Female</subject><subject>Humans</subject><subject>Magnetic resonance imaging</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Medicine</subject><subject>Metastases</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Osteosarcoma</subject><subject>Osteosarcoma - diagnostic imaging</subject><subject>Osteosarcoma - drug therapy</subject><subject>Osteosarcoma - mortality</subject><subject>Patients</subject><subject>Prognosis</subject><subject>Quality</subject><subject>Radionuclide Imaging</subject><subject>Sarcoma</subject><subject>Scintigraphy</subject><subject>Surgery</subject><subject>Survival</subject><subject>Technetium Tc 99m Sestamibi</subject><subject>Treatment 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value of radiological response to chemotherapy in patients with osteosarcoma</title><author>Miwa, Shinji ; Takeuchi, Akihiko ; Shirai, Toshiharu ; Taki, Junichi ; Yamamoto, Norio ; Nishida, Hideji ; Hayashi, Katsuhiro ; Tanzawa, Yoshikazu ; Kimura, Hiroaki ; Igarashi, Kentaro ; Ooi, Akishi ; Tsuchiya, Hiroyuki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c526t-18e0618f4b9df98ad552a10a01eb64c842d6297856979eabd92b14eb08fcf36e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Angiography</topic><topic>Biocompatibility</topic><topic>Bone cancer</topic><topic>Caffeine</topic><topic>Chemotherapy</topic><topic>Clinical outcomes</topic><topic>Computed tomography</topic><topic>Correlation analysis</topic><topic>Disease-Free Survival</topic><topic>Female</topic><topic>Humans</topic><topic>Magnetic resonance imaging</topic><topic>Male</topic><topic>Medical 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Junichi</au><au>Yamamoto, Norio</au><au>Nishida, Hideji</au><au>Hayashi, Katsuhiro</au><au>Tanzawa, Yoshikazu</au><au>Kimura, Hiroaki</au><au>Igarashi, Kentaro</au><au>Ooi, Akishi</au><au>Tsuchiya, Hiroyuki</au><au>Alonso, Marta M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic value of radiological response to chemotherapy in patients with osteosarcoma</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2013-07-29</date><risdate>2013</risdate><volume>8</volume><issue>7</issue><spage>e70015</spage><epage>e70015</epage><pages>e70015-e70015</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Chemotherapy is essential to improve the prognosis of the patients with osteosarcoma, and the response to chemotherapy is an important prognostic factor. In this study, the impact of various radiological examinations on overall survival (OS) and event-free survival (EFS) was evaluated.
Eighty-two patients with high-grade osteosarcoma were included in this study, and we evaluated the following factors for prognostic significance: age (≥40 years), gender (male), tumor location (truncal site), metastatic disease, histological response to chemotherapy, radiological response to chemotherapy assessed using X-ray, angiography, CT, MRI, (201)Tl scintigraphy, and (99m)Tc-MIBI scintigraphy ((99m)Tc-MIBI), and combined radiological score (CRS).
Univariate analyses revealed that metastatic disease, histological response, (99m)Tc-MIBI, and CRS were significantly correlated with OS. Multivariate analyses showed that metastatic disease (OS: HR 35.9, P<0.001; EFS: HR 17.32, P<0.001) was an independent predictor of OS and EFS. Tumor location (HR 36.1, P = 0.003), histological response (HR 31.1, P = 0.036), and (99m)Tc-MIBI (HR 18.4, P = 0.038) were significant prognostic factors for OS. Moreover, CRS was a marginally significant predictor of OS and EFS.
The chemotherapeutic effects evaluated by (99m)Tc-MIBI and CRS could be considered as prognostic factors in osteosarcoma.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>23922892</pmid><doi>10.1371/journal.pone.0070015</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Angiography Biocompatibility Bone cancer Caffeine Chemotherapy Clinical outcomes Computed tomography Correlation analysis Disease-Free Survival Female Humans Magnetic resonance imaging Male Medical imaging Medicine Metastases NMR Nuclear magnetic resonance Osteosarcoma Osteosarcoma - diagnostic imaging Osteosarcoma - drug therapy Osteosarcoma - mortality Patients Prognosis Quality Radionuclide Imaging Sarcoma Scintigraphy Surgery Survival Technetium Tc 99m Sestamibi Treatment Outcome Tumors |
| title | Prognostic value of radiological response to chemotherapy in patients with osteosarcoma |
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