Black tea high-molecular-weight polyphenol stimulates exercise training-induced improvement of endurance capacity in mouse via the link between AMPK and GLUT4
Aerobic exercise can promote "fast-to-slow transition" in skeletal muscles, i.e. an increase in oxidative fibers, mitochondria, and myoglobin and improvement in glucose and lipid metabolism. Here, we found that mice administered Mitochondria Activation Factor (MAF) combined with exercise t...
Gespeichert in:
| Veröffentlicht in: | PloS one 2013-07, Vol.8 (7), p.e69480 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 7 |
| container_start_page | e69480 |
| container_title | PloS one |
| container_volume | 8 |
| creator | Eguchi, Tomoaki Kumagai, Chiaki Fujihara, Takashi Takemasa, Thoru Ozawa, Tetsuo Numata, Osamu |
| description | Aerobic exercise can promote "fast-to-slow transition" in skeletal muscles, i.e. an increase in oxidative fibers, mitochondria, and myoglobin and improvement in glucose and lipid metabolism. Here, we found that mice administered Mitochondria Activation Factor (MAF) combined with exercise training could run longer distances and for a longer time compared with the exercise only group; MAF is a high-molecular-weight polyphenol purified from black tea. Furthermore, MAF intake combined with exercise training increased phosphorylation of AMPK and mRNA level of glucose transporter 4 (GLUT4). Thus, our data demonstrate for the first time that MAF activates exercise training-induced intracellular signaling pathways that involve AMPK, and improves endurance capacity. |
| doi_str_mv | 10.1371/journal.pone.0069480 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_plos_</sourceid><recordid>TN_cdi_plos_journals_1440993911</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_6251c11e77844f73894f04c7fca8b06d</doaj_id><sourcerecordid>3095101331</sourcerecordid><originalsourceid>FETCH-LOGICAL-c636t-17592c30b2eaca55de1c5f9869095f37cb0725c585ef8a29f0bad4d5990e726e3</originalsourceid><addsrcrecordid>eNp1Uk1v1DAQjRCIlsI_QGCJcxZ_xHF8QWorKBWL4NCeLceZ7Hrr2MF2WvbP8FvJstuqPXDyeOa9N0-jVxRvCV4QJsjHTZii124xBg8LjGtZNfhZcUwko2VNMXv-qD4qXqW0wZizpq5fFkeUSUoFkcfFnzOnzQ3KoNHartblEByYyelY3sH8z2gMbjuuwQeHUrbDPMqQEPyGaGwClKO23vpVaX03GeiQHcYYbmEAn1HoEcztqL0BZPSojc1bZD0awjRzb61GeQ3IWX-DWsh3AB6dfv_5DWnfoYvl9VX1unjRa5fgzeE9Ka6_fL46_1ouf1xcnp8uS1OzOpdEcEkNwy0FbTTnHRDDe9nUEkveM2FaLCg3vOHQN5rKHre6qzouJQZBa2Anxfu97uhCUofTJkWqCkvJJCEz4nKP6ILeqDHaQcetCtqqf40QV0rHbI0DVVNODCEgRFNVvWCNrHpcGdEb3bS47matT4dtUztAZ-ZbRe2eiD6deLtWq3CrmKBVw3dmPhwEYvg1Qcr_sVztUSaGlCL0DxsIVrsM3bPULkPqkKGZ9u6xuwfSfWjYX-hLyEg</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1440993911</pqid></control><display><type>article</type><title>Black tea high-molecular-weight polyphenol stimulates exercise training-induced improvement of endurance capacity in mouse via the link between AMPK and GLUT4</title><source>MEDLINE</source><source>Public Library of Science</source><source>DOAJ Directory of Open Access Journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><source>EZB Electronic Journals Library</source><creator>Eguchi, Tomoaki ; Kumagai, Chiaki ; Fujihara, Takashi ; Takemasa, Thoru ; Ozawa, Tetsuo ; Numata, Osamu</creator><contributor>Bai, Yidong</contributor><creatorcontrib>Eguchi, Tomoaki ; Kumagai, Chiaki ; Fujihara, Takashi ; Takemasa, Thoru ; Ozawa, Tetsuo ; Numata, Osamu ; Bai, Yidong</creatorcontrib><description>Aerobic exercise can promote "fast-to-slow transition" in skeletal muscles, i.e. an increase in oxidative fibers, mitochondria, and myoglobin and improvement in glucose and lipid metabolism. Here, we found that mice administered Mitochondria Activation Factor (MAF) combined with exercise training could run longer distances and for a longer time compared with the exercise only group; MAF is a high-molecular-weight polyphenol purified from black tea. Furthermore, MAF intake combined with exercise training increased phosphorylation of AMPK and mRNA level of glucose transporter 4 (GLUT4). Thus, our data demonstrate for the first time that MAF activates exercise training-induced intracellular signaling pathways that involve AMPK, and improves endurance capacity.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0069480</identifier><identifier>PMID: 23922719</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Aerobic capacity ; AMP-Activated Protein Kinases - metabolism ; Animals ; Biology ; Biosynthesis ; Black tea ; Caffeine ; Chemistry ; Diabetes ; Durability ; Endurance ; Endurance capacity ; Environmental science ; Enzyme Activation - drug effects ; Exercise ; Experiments ; Fatty acids ; Fibers ; Fitness training programs ; Gene Expression Regulation - drug effects ; Glucose ; Glucose metabolism ; Glucose transporter ; Glucose Transporter Type 4 - genetics ; Glucose Transporter Type 4 - metabolism ; Intracellular signalling ; Kinases ; Lipid metabolism ; Medicine ; Metabolism ; Mice ; Mice, Inbred C57BL ; Mitochondria ; Molecular Weight ; mRNA ; Muscle Fibers, Skeletal - drug effects ; Muscle Fibers, Skeletal - metabolism ; Muscles ; Musculoskeletal system ; Myoglobins ; Obesity ; Oxidation-Reduction - drug effects ; Phosphorylation ; Physical Conditioning, Animal ; Physical Endurance - drug effects ; Physical fitness ; Physical training ; Polyphenols ; Polyphenols - administration & dosage ; Polyphenols - pharmacology ; Proteins ; Respiration ; RNA, Messenger - genetics ; RNA, Messenger - metabolism ; Rodents ; Skeletal muscle ; Tea ; Tea - chemistry ; Training</subject><ispartof>PloS one, 2013-07, Vol.8 (7), p.e69480</ispartof><rights>2013 Eguchi et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2013 Eguchi et al 2013 Eguchi et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c636t-17592c30b2eaca55de1c5f9869095f37cb0725c585ef8a29f0bad4d5990e726e3</citedby><cites>FETCH-LOGICAL-c636t-17592c30b2eaca55de1c5f9869095f37cb0725c585ef8a29f0bad4d5990e726e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3724851/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3724851/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2100,2919,23857,27915,27916,53782,53784,79361,79362</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23922719$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Bai, Yidong</contributor><creatorcontrib>Eguchi, Tomoaki</creatorcontrib><creatorcontrib>Kumagai, Chiaki</creatorcontrib><creatorcontrib>Fujihara, Takashi</creatorcontrib><creatorcontrib>Takemasa, Thoru</creatorcontrib><creatorcontrib>Ozawa, Tetsuo</creatorcontrib><creatorcontrib>Numata, Osamu</creatorcontrib><title>Black tea high-molecular-weight polyphenol stimulates exercise training-induced improvement of endurance capacity in mouse via the link between AMPK and GLUT4</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Aerobic exercise can promote "fast-to-slow transition" in skeletal muscles, i.e. an increase in oxidative fibers, mitochondria, and myoglobin and improvement in glucose and lipid metabolism. Here, we found that mice administered Mitochondria Activation Factor (MAF) combined with exercise training could run longer distances and for a longer time compared with the exercise only group; MAF is a high-molecular-weight polyphenol purified from black tea. Furthermore, MAF intake combined with exercise training increased phosphorylation of AMPK and mRNA level of glucose transporter 4 (GLUT4). Thus, our data demonstrate for the first time that MAF activates exercise training-induced intracellular signaling pathways that involve AMPK, and improves endurance capacity.</description><subject>Aerobic capacity</subject><subject>AMP-Activated Protein Kinases - metabolism</subject><subject>Animals</subject><subject>Biology</subject><subject>Biosynthesis</subject><subject>Black tea</subject><subject>Caffeine</subject><subject>Chemistry</subject><subject>Diabetes</subject><subject>Durability</subject><subject>Endurance</subject><subject>Endurance capacity</subject><subject>Environmental science</subject><subject>Enzyme Activation - drug effects</subject><subject>Exercise</subject><subject>Experiments</subject><subject>Fatty acids</subject><subject>Fibers</subject><subject>Fitness training programs</subject><subject>Gene Expression Regulation - drug effects</subject><subject>Glucose</subject><subject>Glucose metabolism</subject><subject>Glucose transporter</subject><subject>Glucose Transporter Type 4 - genetics</subject><subject>Glucose Transporter Type 4 - metabolism</subject><subject>Intracellular signalling</subject><subject>Kinases</subject><subject>Lipid metabolism</subject><subject>Medicine</subject><subject>Metabolism</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mitochondria</subject><subject>Molecular Weight</subject><subject>mRNA</subject><subject>Muscle Fibers, Skeletal - drug effects</subject><subject>Muscle Fibers, Skeletal - metabolism</subject><subject>Muscles</subject><subject>Musculoskeletal system</subject><subject>Myoglobins</subject><subject>Obesity</subject><subject>Oxidation-Reduction - drug effects</subject><subject>Phosphorylation</subject><subject>Physical Conditioning, Animal</subject><subject>Physical Endurance - drug effects</subject><subject>Physical fitness</subject><subject>Physical training</subject><subject>Polyphenols</subject><subject>Polyphenols - administration & dosage</subject><subject>Polyphenols - pharmacology</subject><subject>Proteins</subject><subject>Respiration</subject><subject>RNA, Messenger - genetics</subject><subject>RNA, Messenger - metabolism</subject><subject>Rodents</subject><subject>Skeletal muscle</subject><subject>Tea</subject><subject>Tea - chemistry</subject><subject>Training</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNp1Uk1v1DAQjRCIlsI_QGCJcxZ_xHF8QWorKBWL4NCeLceZ7Hrr2MF2WvbP8FvJstuqPXDyeOa9N0-jVxRvCV4QJsjHTZii124xBg8LjGtZNfhZcUwko2VNMXv-qD4qXqW0wZizpq5fFkeUSUoFkcfFnzOnzQ3KoNHartblEByYyelY3sH8z2gMbjuuwQeHUrbDPMqQEPyGaGwClKO23vpVaX03GeiQHcYYbmEAn1HoEcztqL0BZPSojc1bZD0awjRzb61GeQ3IWX-DWsh3AB6dfv_5DWnfoYvl9VX1unjRa5fgzeE9Ka6_fL46_1ouf1xcnp8uS1OzOpdEcEkNwy0FbTTnHRDDe9nUEkveM2FaLCg3vOHQN5rKHre6qzouJQZBa2Anxfu97uhCUofTJkWqCkvJJCEz4nKP6ILeqDHaQcetCtqqf40QV0rHbI0DVVNODCEgRFNVvWCNrHpcGdEb3bS47matT4dtUztAZ-ZbRe2eiD6deLtWq3CrmKBVw3dmPhwEYvg1Qcr_sVztUSaGlCL0DxsIVrsM3bPULkPqkKGZ9u6xuwfSfWjYX-hLyEg</recordid><startdate>20130726</startdate><enddate>20130726</enddate><creator>Eguchi, Tomoaki</creator><creator>Kumagai, Chiaki</creator><creator>Fujihara, Takashi</creator><creator>Takemasa, Thoru</creator><creator>Ozawa, Tetsuo</creator><creator>Numata, Osamu</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20130726</creationdate><title>Black tea high-molecular-weight polyphenol stimulates exercise training-induced improvement of endurance capacity in mouse via the link between AMPK and GLUT4</title><author>Eguchi, Tomoaki ; Kumagai, Chiaki ; Fujihara, Takashi ; Takemasa, Thoru ; Ozawa, Tetsuo ; Numata, Osamu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c636t-17592c30b2eaca55de1c5f9869095f37cb0725c585ef8a29f0bad4d5990e726e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Aerobic capacity</topic><topic>AMP-Activated Protein Kinases - metabolism</topic><topic>Animals</topic><topic>Biology</topic><topic>Biosynthesis</topic><topic>Black tea</topic><topic>Caffeine</topic><topic>Chemistry</topic><topic>Diabetes</topic><topic>Durability</topic><topic>Endurance</topic><topic>Endurance capacity</topic><topic>Environmental science</topic><topic>Enzyme Activation - drug effects</topic><topic>Exercise</topic><topic>Experiments</topic><topic>Fatty acids</topic><topic>Fibers</topic><topic>Fitness training programs</topic><topic>Gene Expression Regulation - drug effects</topic><topic>Glucose</topic><topic>Glucose metabolism</topic><topic>Glucose transporter</topic><topic>Glucose Transporter Type 4 - genetics</topic><topic>Glucose Transporter Type 4 - metabolism</topic><topic>Intracellular signalling</topic><topic>Kinases</topic><topic>Lipid metabolism</topic><topic>Medicine</topic><topic>Metabolism</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Mitochondria</topic><topic>Molecular Weight</topic><topic>mRNA</topic><topic>Muscle Fibers, Skeletal - drug effects</topic><topic>Muscle Fibers, Skeletal - metabolism</topic><topic>Muscles</topic><topic>Musculoskeletal system</topic><topic>Myoglobins</topic><topic>Obesity</topic><topic>Oxidation-Reduction - drug effects</topic><topic>Phosphorylation</topic><topic>Physical Conditioning, Animal</topic><topic>Physical Endurance - drug effects</topic><topic>Physical fitness</topic><topic>Physical training</topic><topic>Polyphenols</topic><topic>Polyphenols - administration & dosage</topic><topic>Polyphenols - pharmacology</topic><topic>Proteins</topic><topic>Respiration</topic><topic>RNA, Messenger - genetics</topic><topic>RNA, Messenger - metabolism</topic><topic>Rodents</topic><topic>Skeletal muscle</topic><topic>Tea</topic><topic>Tea - chemistry</topic><topic>Training</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Eguchi, Tomoaki</creatorcontrib><creatorcontrib>Kumagai, Chiaki</creatorcontrib><creatorcontrib>Fujihara, Takashi</creatorcontrib><creatorcontrib>Takemasa, Thoru</creatorcontrib><creatorcontrib>Ozawa, Tetsuo</creatorcontrib><creatorcontrib>Numata, Osamu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>ProQuest Nursing and Allied Health Journals</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health Medical collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central</collection><collection>Advanced Technologies & Aerospace Database (1962 - current)</collection><collection>ProQuest Agriculture & Environmental Science Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agriculture Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>ProQuest Biological Science Journals</collection><collection>ProQuest Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Eguchi, Tomoaki</au><au>Kumagai, Chiaki</au><au>Fujihara, Takashi</au><au>Takemasa, Thoru</au><au>Ozawa, Tetsuo</au><au>Numata, Osamu</au><au>Bai, Yidong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Black tea high-molecular-weight polyphenol stimulates exercise training-induced improvement of endurance capacity in mouse via the link between AMPK and GLUT4</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2013-07-26</date><risdate>2013</risdate><volume>8</volume><issue>7</issue><spage>e69480</spage><pages>e69480-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Aerobic exercise can promote "fast-to-slow transition" in skeletal muscles, i.e. an increase in oxidative fibers, mitochondria, and myoglobin and improvement in glucose and lipid metabolism. Here, we found that mice administered Mitochondria Activation Factor (MAF) combined with exercise training could run longer distances and for a longer time compared with the exercise only group; MAF is a high-molecular-weight polyphenol purified from black tea. Furthermore, MAF intake combined with exercise training increased phosphorylation of AMPK and mRNA level of glucose transporter 4 (GLUT4). Thus, our data demonstrate for the first time that MAF activates exercise training-induced intracellular signaling pathways that involve AMPK, and improves endurance capacity.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>23922719</pmid><doi>10.1371/journal.pone.0069480</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2013-07, Vol.8 (7), p.e69480 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1440993911 |
| source | MEDLINE; Public Library of Science; DOAJ Directory of Open Access Journals; PubMed Central; Free Full-Text Journals in Chemistry; EZB Electronic Journals Library |
| subjects | Aerobic capacity AMP-Activated Protein Kinases - metabolism Animals Biology Biosynthesis Black tea Caffeine Chemistry Diabetes Durability Endurance Endurance capacity Environmental science Enzyme Activation - drug effects Exercise Experiments Fatty acids Fibers Fitness training programs Gene Expression Regulation - drug effects Glucose Glucose metabolism Glucose transporter Glucose Transporter Type 4 - genetics Glucose Transporter Type 4 - metabolism Intracellular signalling Kinases Lipid metabolism Medicine Metabolism Mice Mice, Inbred C57BL Mitochondria Molecular Weight mRNA Muscle Fibers, Skeletal - drug effects Muscle Fibers, Skeletal - metabolism Muscles Musculoskeletal system Myoglobins Obesity Oxidation-Reduction - drug effects Phosphorylation Physical Conditioning, Animal Physical Endurance - drug effects Physical fitness Physical training Polyphenols Polyphenols - administration & dosage Polyphenols - pharmacology Proteins Respiration RNA, Messenger - genetics RNA, Messenger - metabolism Rodents Skeletal muscle Tea Tea - chemistry Training |
| title | Black tea high-molecular-weight polyphenol stimulates exercise training-induced improvement of endurance capacity in mouse via the link between AMPK and GLUT4 |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-14T19%3A56%3A29IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Black%20tea%20high-molecular-weight%20polyphenol%20stimulates%20exercise%20training-induced%20improvement%20of%20endurance%20capacity%20in%20mouse%20via%20the%20link%20between%20AMPK%20and%20GLUT4&rft.jtitle=PloS%20one&rft.au=Eguchi,%20Tomoaki&rft.date=2013-07-26&rft.volume=8&rft.issue=7&rft.spage=e69480&rft.pages=e69480-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0069480&rft_dat=%3Cproquest_plos_%3E3095101331%3C/proquest_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1440993911&rft_id=info:pmid/23922719&rft_doaj_id=oai_doaj_org_article_6251c11e77844f73894f04c7fca8b06d&rfr_iscdi=true |