NF-κB regulates mesenchymal transition for the induction of non-small cell lung cancer initiating cells

The epithelial-to-mesenchymal transition (EMT) is a de-differentiation process that has been implicated in metastasis and the generation of cancer initiating cells (CICs) in solid tumors. To examine EMT in non-small cell lung cancer (NSCLC), we utilized a three dimensional (3D) cell culture system i...

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Veröffentlicht in:	PloS one 2013-07, Vol.8 (7), p.e68597
Hauptverfasser:	Kumar, Manish, Allison, David F, Baranova, Natalya N, Wamsley, J Jacob, Katz, Adam J, Bekiranov, Stefan, Jones, David R, Mayo, Marty W
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biochemistry Biology Breast cancer Cancer Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - metabolism Carcinoma, Non-Small-Cell Lung - pathology Cell adhesion & migration Cell culture Cell Culture Techniques Cell Line, Tumor Cell Transformation, Neoplastic - genetics Cell Transformation, Neoplastic - metabolism Cytokines Dilution Disease Models, Animal Epigenetics Epithelial-Mesenchymal Transition - genetics Fibroblasts Gene expression Gene Expression Regulation, Neoplastic Growth factors Humans Hypotheses Invasiveness Kinases KLF4 protein Lung cancer Lung diseases Lung Neoplasms - genetics Lung Neoplasms - metabolism Lung Neoplasms - pathology Mathematics Medical prognosis Medicine Mesenchyme Metastases Metastasis Mice Neoplasm Metastasis Neoplastic Stem Cells - metabolism NF-kappa B - genetics NF-kappa B - metabolism NF-κB protein Non-small cell lung carcinoma Oct-4 protein Phenotype Snail protein Solid tumors Spheroids Spheroids, Cellular Stem cells Surgery Transcription factors Transforming growth factor-a Transforming growth factor-b Tumor Cells, Cultured Tumor necrosis factor-TNF Tumor necrosis factor-α Tumors
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