Patterns of population differentiation and natural selection on the celiac disease background risk network

Celiac disease is a common small intestinal inflammatory condition induced by wheat gluten and related proteins from rye and barley. Left untreated, the clinical presentation of CD can include failure to thrive, malnutrition, and distension in juveniles. The disease can additionally lead to vitamin...

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Veröffentlicht in:	PloS one 2013-07, Vol.8 (7), p.e70564-e70564
Hauptverfasser:	Sams, Aaron, Hawks, John
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptation Agricultural production Anemia Autoimmune diseases Barley Biocompatibility Biology Biomedical materials Celiac disease Celiac Disease - genetics Celiac Disease - immunology Demographics Demography Differentiation Disease Distension Europe Evolution & development Evolution, Molecular Fitness Gene loci Gene Regulatory Networks - genetics Gene Regulatory Networks - immunology Genetic Predisposition to Disease - genetics Genetics Genetics, Population Genome, Human - genetics Genome-Wide Association Study Genomes Gluten Haplotypes Health risk assessment Health risks Histocompatibility antigen HLA Holocene Humans Hunter-gatherers Hypotheses Immune system Immunity Immunity - genetics Immunology Inflammation Intestine Localization Loci Malnutrition Medicine Natural selection Neolithic Null hypothesis Osteoporosis Polymorphism, Single Nucleotide Population Population differentiation Positive selection Proteins Reproductive fitness Risk Risk Factors Rye Selection, Genetic Social and Behavioral Sciences Studies Triticum Vitamin deficiency Wheat
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