Characterization of a new chronic lymphocytic leukemia cell line for mechanistic in vitro and in vivo studies relevant to disease

Studies of chronic lymphocytic leukemia (CLL) have yielded substantial progress, however a lack of immortalized cell lines representative of the primary disease has hampered a full understanding of disease pathogenesis and development of new treatments. Here we describe a novel CLL cell line (OSU-CL...

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Veröffentlicht in:	PloS one 2013-10, Vol.8 (10), p.e76607
Hauptverfasser:	Hertlein, Erin, Beckwith, Kyle A, Lozanski, Gerard, Chen, Timothy L, Towns, William H, Johnson, Amy J, Lehman, Amy, Ruppert, Amy S, Bolon, Brad, Andritsos, Leslie, Lozanski, Arletta, Rassenti, Laura, Zhao, Weiqiang, Jarvinen, Tiina M, Senter, Leigha, Croce, Carlo M, Symer, David E, de la Chapelle, Albert, Heerema, Nyla A, Byrd, John C
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animal models Animals Apoptosis B cells Biotechnology Bone marrow Bone marrow transplantation Cancer Cancer research CD5 antigen Cell Culture Techniques Cell Line, Tumor Cell migration Cell Movement Cell Transformation, Viral Chemokines Chromosomes Chronic lymphocytic leukemia Development and progression DNA microarrays Gene expression Genes Genetic transformation Genetics Health risk assessment Hematology Herpesvirus 4, Human - physiology Humans Immunology In vivo methods and tests Internal medicine Kinases Leukemia Leukemia, Lymphocytic, Chronic, B-Cell - genetics Leukemia, Lymphocytic, Chronic, B-Cell - pathology Lymphatic leukemia Lymphocyte receptors Lymphocytes B Medical treatment Medicine Mice Mutation Pathogenesis Pathology Peripheral blood Phenotype Spleen Transformation Trisomy Virology
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