Genetic background can result in a marked or minimal effect of gene knockout (GPR55 and CB2 receptor) in experimental autoimmune encephalomyelitis models of multiple sclerosis

Endocannabinoids and some phytocannabinoids bind to CB1 and CB2 cannabinoid receptors, transient receptor potential vanilloid one (TRPV1) receptor and the orphan G protein receptor fifty-five (GPR55). Studies using C57BL/10 and C57BL/6 (Cnr2 (tm1Zim)) CB2 cannabinoid receptor knockout mice have demo...

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Veröffentlicht in:	PloS one 2013-10, Vol.8 (10), p.e76907
Hauptverfasser:	Sisay, Sofia, Pryce, Gareth, Jackson, Samuel J, Tanner, Carolyn, Ross, Ruth A, Michael, Gregory J, Selwood, David L, Giovannoni, Gavin, Baker, David
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animal models Animals Autoantigens Autoimmune diseases Autoimmunity Cannabinoid CB1 receptors Cannabinoid CB2 receptors Cannabis Capsaicin receptors Clonal deletion Dentistry Disease Models, Animal Disease susceptibility Encephalomyelitis Encephalomyelitis, Autoimmune, Experimental - genetics Encephalomyelitis, Autoimmune, Experimental - immunology Endocannabinoid system Experimental allergic encephalomyelitis Female Gene Deletion Gene Knockout Techniques Genes Glycoproteins House mouse Immune response Immune system Immunomodulation Immunomodulation - genetics Immunosuppression Influence Laboratory animals Ligands Lymphocytes T Male Marijuana Medical marijuana Medicine Mice Multiple sclerosis Multiple Sclerosis - genetics Multiple Sclerosis - immunology Myelin Myelin proteins Nervous system Oligodendrocyte-myelin glycoprotein Pharmacology Phenotype Proteins Receptor, Cannabinoid, CB2 - deficiency Receptor, Cannabinoid, CB2 - genetics Receptors Receptors, Cannabinoid - deficiency Receptors, Cannabinoid - genetics Rodents Species Specificity Spinal cord T cells Tetrahydrocannabinol Transient receptor potential proteins
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