Androgen receptor CAG repeats length polymorphism and the risk of polycystic ovarian syndrome (PCOS)

Polycystic ovarian syndrome (PCOS) refers to an inheritable androgen excess disorder characterized by multiple small follicles located at the ovarian periphery. Hyperandrogenism in PCOS, and inverse correlation between androgen receptor (AR) CAG numbers and AR function, led us to hypothesize that CA...

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Veröffentlicht in:	PloS one 2013-10, Vol.8 (10), p.e75709-e75709
Hauptverfasser:	Rajender, Singh, Carlus, Silas Justin, Bansal, Sandeep Kumar, Negi, Mahendra Pal Singh, Negi, Mahendra Pratap Singh, Sadasivam, Nirmala, Sadasivam, Muthusamy Narayanan, Thangaraj, Kumarasamy
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Alleles Androgen receptors Androgens Correlation Correlation analysis Data processing Deactivation Female Follicles Frequency distribution Genetic aspects Genetic Predisposition to Disease Genotype Hair Hospitals Humans Hyperandrogenism - genetics Inactivation Infertility Meta-analysis Middle Aged Molecular biology Polycystic ovary syndrome Polycystic Ovary Syndrome - genetics Polycystic Ovary Syndrome - metabolism Polyglutamine Polymorphism Polymorphism, Genetic Receptors, Androgen - genetics Receptors, Androgen - metabolism Representations Risk Subgroups Systematic review Testosterone Trinucleotide Repeats Women X chromosomes X-chromosome inactivation
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