Oxidative stress in mammalian cells impinges on the cysteines redox state of human XRCC3 protein and on its cellular localization

In vertebrates, XRCC3 is one of the five Rad51 paralogs that plays a central role in homologous recombination (HR), a key pathway for maintaining genomic stability. While investigating the potential role of human XRCC3 (hXRCC3) in the inhibition of DNA replication induced by UVA radiation, we discov...

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Veröffentlicht in:	PloS one 2013-10, Vol.8 (10), p.e75751
Hauptverfasser:	Girard, Pierre-Marie, Graindorge, Dany, Smirnova, Violetta, Rigolet, Pascal, Francesconi, Stefania, Scanlon, Susan, Sage, Evelyne
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Camptothecin Camptothecin - pharmacology Cell Survival Cell Survival - drug effects Cell Survival - physiology Cells (Biology) Chemical bonds CHO Cells Chromatin Cricetinae Cricetulus Cysteine Cysteine - metabolism Cystine Cytoplasm Cytotoxicity Deoxyribonucleic acid DNA DNA biosynthesis DNA Damage DNA Damage - drug effects DNA Repair DNA Repair - drug effects DNA Replication DNA Replication - drug effects DNA-Binding Proteins DNA-Binding Proteins - metabolism Electrophoretic mobility Environmental factors Exposure Gel electrophoresis Glutathione Homologous Recombination Homologous Recombination - drug effects Homologous Recombination - physiology Homology Humans Life Sciences Localization Mammalian cells Nuclei Nuclei (cytology) Oxidants Oxidation Oxidation-Reduction Oxidative Stress Oxidative Stress - drug effects Oxidative Stress - physiology Oxidizing agents Photosensitization Proteins Radiation Radiation (Physics) Reactive Oxygen Species Reactive Oxygen Species - metabolism Redox properties Sodium lauryl sulfate U.V. radiation Ultraviolet radiation Vertebrates
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