Epigenetic priming of AML blasts for all-trans retinoic acid-induced differentiation by the HDAC class-I selective inhibitor entinostat

All-trans retinoic acid (ATRA) has only limited single agent activity in AML without the PML-RARα fusion (non-M3 AML). In search of a sensitizing strategy to overcome this relative ATRA resistance, we investigated the potency of the HDAC class-I selective inhibitor entinostat in AML cell lines Kasum...

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Veröffentlicht in:	PloS one 2013-10, Vol.8 (10), p.e75258
Hauptverfasser:	Blagitko-Dorfs, Nadja, Jiang, Yi, Duque-Afonso, Jesús, Hiller, Jan, Yalcin, Arzu, Greve, Gabriele, Abdelkarim, Mahmoud, Hackanson, Björn, Lübbert, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	5-aza-2'-deoxycytidine Acids Activation Adult Aged Analysis Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Apoptosis Benzamides - pharmacology Benzamides - therapeutic use Biotechnology Cancer therapies Cell differentiation Cell Differentiation - drug effects Cell Differentiation - genetics Cell Line Chemotherapy Chromatin Demethylation Deoxyribonucleic acid Differentiation DNA DNA methylation DNA Methylation - drug effects Drug Interactions Epigenesis, Genetic - drug effects Epigenetic inheritance Epigenetics Female Gene silencing Genes Genetic engineering Hematology Histone deacetylase Humans Inhibitors Laboratories Leukemia Leukemia, Myeloid, Acute - drug therapy Leukemia, Myeloid, Acute - genetics Ligands Lung cancer Male Methylation Middle Aged Oncology Patients Pharmacology Priming Promoter Regions, Genetic - drug effects Pyridines - pharmacology Pyridines - therapeutic use Retinoic acid RNA polymerase Sensitizing Solid tumors Tretinoin - pharmacology Tretinoin - therapeutic use
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