Relationship between cerebrospinal fluid biomarkers for inflammation, demyelination and neurodegeneration in acute optic neuritis

Various inflammatory biomarkers show prognostic potential for multiple sclerosis (MS)-risk after clinically isolated syndromes. However, biomarkers are often examined singly and their interrelation and precise aspects of their associated pathological processes remain unclear. Clarification of these...

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Veröffentlicht in:	PloS one 2013-10, Vol.8 (10), p.e77163-e77163
Hauptverfasser:	Modvig, Signe, Degn, Matilda, Horwitz, Henrik, Cramer, Stig P, Larsson, Henrik B W, Wanscher, Benedikte, Sellebjerg, Finn, Frederiksen, Jette L
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age Biocompatibility Biological markers Biomarkers Biomarkers - cerebrospinal fluid Biomedical materials Cerebrospinal fluid Chitinase Correlation analysis Cumulative damage CXCL10 protein CXCL13 protein Demyelinating Diseases - cerebrospinal fluid Demyelinating Diseases - complications Demyelination Disabilities Female Gelatinase B Humans Immunoglobulin G Infiltration Inflammation Inflammation - cerebrospinal fluid Inflammation - complications Lesions Leukocytes Magnetic resonance imaging Male Matrix metalloproteinase Medical research Metalloproteinase Middle Aged Multiple sclerosis Multiple Sclerosis - cerebrospinal fluid Multiple Sclerosis - complications Multiple Sclerosis - epidemiology Myelin Myelin basic protein Myelin proteins Neuritis Neurodegeneration Neurodegenerative Diseases - cerebrospinal fluid Neurodegenerative Diseases - complications Neurology NMR Nuclear magnetic resonance Optic neuritis Optic Neuritis - cerebrospinal fluid Optic Neuritis - complications Osteopontin Parameters Prospective Studies Proteins Risk Risk Factors Substantia alba White blood cells
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