Single-cell analysis reveals early manifestation of cancerous phenotype in pre-malignant esophageal cells

Cellular heterogeneity plays a pivotal role in a variety of functional processes in vivo including carcinogenesis. However, our knowledge about cell-to-cell diversity and how differences in individual cells manifest in alterations at the population level remains very limited mainly due to the lack o...

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Veröffentlicht in:	PloS one 2013-10, Vol.8 (10), p.e75365
Hauptverfasser:	Wang, Jiangxin, Shi, Xu, Johnson, Roger H, Kelbauskas, Laimonas, Zhang, Weiwen, Meldrum, Deirdre R
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - genetics Adenocarcinoma - metabolism Adenocarcinoma - pathology Analysis Apoptosis Barrett Esophagus - genetics Barrett Esophagus - metabolism Barrett Esophagus - pathology Cancer Carcinogenesis Carcinogens Cell growth Cell Line Data analysis Data processing Deoxyribonucleic acid Disease Progression DNA DNA, Mitochondrial - genetics DNA, Mitochondrial - metabolism Epithelial Cells - metabolism Epithelial Cells - pathology Esophageal Neoplasms - genetics Esophageal Neoplasms - metabolism Esophageal Neoplasms - pathology Esophagus Esophagus - metabolism Esophagus - pathology Gene expression Genes Genetic aspects Heterogeneity Humans Hypoxia Information management Measurement methods Membrane potential Membrane Potential, Mitochondrial - physiology Mitochondria Mitochondria - genetics Mitochondria - metabolism Mitochondria - pathology Mitochondrial DNA Molecular chains Molecular modelling Oxidative stress Phenotype Phenotypes Phosphorylation RNA Single-Cell Analysis Skewness Tumors
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