Microcirculatory rarefaction in South Asians - a potential mechanism for increased cardiovascular risk and diabetes
People of South Asian descent have an increased risk of cardiovascular disease (CVD) and diabetes, but little is known about the microcirculation in South Asian people despite evidence that this plays an important role in the aetiology of CVD. We compared the retinal microcirculation in a population...
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| description | People of South Asian descent have an increased risk of cardiovascular disease (CVD) and diabetes, but little is known about the microcirculation in South Asian people despite evidence that this plays an important role in the aetiology of CVD. We compared the retinal microcirculation in a population-based sample of 287 middle-aged adults (144 European 143 South Asian) matched for age and sex. Retinal photographs were taken and analysed using a validated semi-automated program and microvascular measures were compared. Blood pressure, anthropometry and fasting bloods were also measured. South Asians had significantly fewer arteriolar and venular vessels and bifurcations. Arterioles and venules were longer and venules were also more tortuous in South Asians. These differences were not explained by adjustment for traditional risk factors including blood pressure, body mass index, diabetes or measures of insulin resistance. People of South Asian descent have rarefaction of the retinal microcirculation compared to age-sex matched individuals of European descent. Reduced microvascular density could contribute to the elevated risk of CVD and impaired glucose tolerance in South Asian people. |
| doi_str_mv | 10.1371/journal.pone.0076680 |
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We compared the retinal microcirculation in a population-based sample of 287 middle-aged adults (144 European 143 South Asian) matched for age and sex. Retinal photographs were taken and analysed using a validated semi-automated program and microvascular measures were compared. Blood pressure, anthropometry and fasting bloods were also measured. South Asians had significantly fewer arteriolar and venular vessels and bifurcations. Arterioles and venules were longer and venules were also more tortuous in South Asians. These differences were not explained by adjustment for traditional risk factors including blood pressure, body mass index, diabetes or measures of insulin resistance. People of South Asian descent have rarefaction of the retinal microcirculation compared to age-sex matched individuals of European descent. Reduced microvascular density could contribute to the elevated risk of CVD and impaired glucose tolerance in South Asian people.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0076680</identifier><identifier>PMID: 24116136</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adults ; Aged ; Anthropometry ; Arterioles ; Arterioles - pathology ; Arterioles - physiopathology ; Asian people ; Asians ; Asians - statistics & numerical data ; Atherosclerosis ; Bifurcations ; Blood ; Blood Glucose - metabolism ; Blood Pressure ; Blood vessels ; Body mass ; Body mass index ; Body size ; Cardiovascular disease ; Cardiovascular diseases ; Cardiovascular Diseases - blood ; Cardiovascular Diseases - ethnology ; Cardiovascular Diseases - physiopathology ; Comparative analysis ; Coronary vessels ; Descent ; Diabetes ; Diabetes mellitus ; Diabetes Mellitus - blood ; Diabetes Mellitus - ethnology ; Diabetes Mellitus - physiopathology ; Diabetic retinopathy ; Ethnicity ; Family medical history ; Fasting - blood ; Female ; Glucose tolerance ; Glycated Hemoglobin A - metabolism ; Health risks ; Humans ; Hypertension ; Insulin ; Insulin - blood ; Insulin resistance ; Lipids - blood ; Male ; Medicine ; Microcirculation ; Microvasculature ; Middle Aged ; Multivariate Analysis ; Population ; Primary care ; Rarefaction ; Regression Analysis ; Retina ; Retinal Vessels - pathology ; Retinal Vessels - physiopathology ; Risk analysis ; Risk Assessment - methods ; Risk Assessment - statistics & numerical data ; Risk Factors ; Sex ; Venules - pathology ; Venules - physiopathology ; Whites - statistics & numerical data</subject><ispartof>PloS one, 2013-10, Vol.8 (10), p.e76680-e76680</ispartof><rights>COPYRIGHT 2013 Public Library of Science</rights><rights>2013 Hughes et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 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Reduced microvascular density could contribute to the elevated risk of CVD and impaired glucose tolerance in South Asian people.</description><subject>Adults</subject><subject>Aged</subject><subject>Anthropometry</subject><subject>Arterioles</subject><subject>Arterioles - pathology</subject><subject>Arterioles - physiopathology</subject><subject>Asian people</subject><subject>Asians</subject><subject>Asians - statistics & numerical data</subject><subject>Atherosclerosis</subject><subject>Bifurcations</subject><subject>Blood</subject><subject>Blood Glucose - metabolism</subject><subject>Blood Pressure</subject><subject>Blood vessels</subject><subject>Body mass</subject><subject>Body mass index</subject><subject>Body size</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular diseases</subject><subject>Cardiovascular Diseases - blood</subject><subject>Cardiovascular Diseases - ethnology</subject><subject>Cardiovascular Diseases - physiopathology</subject><subject>Comparative analysis</subject><subject>Coronary vessels</subject><subject>Descent</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetes Mellitus - 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physiopathology</subject><subject>Risk analysis</subject><subject>Risk Assessment - methods</subject><subject>Risk Assessment - statistics & numerical data</subject><subject>Risk Factors</subject><subject>Sex</subject><subject>Venules - pathology</subject><subject>Venules - physiopathology</subject><subject>Whites - statistics & numerical data</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk11v0zAUhiMEYqPwDxBYQkJw0WLHie3cIFUTH5WGJjHg1jo5cVqXNO7sZGL_HmfNpgbtAvnClv2c1z6vz0mSl4wuGJfsw9b1voVmsXetWVAqhVD0UXLKCp7ORUr546P1SfIshC2lOVdCPE1O0owxwbg4TcI3i96h9dg30Dl_Qzx4UwN21rXEtuTS9d2GLIOFNpA5AbJ3nWk7Cw3ZGdxAa8OO1M5HFr2BYCqC4CvrriEMmp54G34TaCtSWShNZ8Lz5EkNTTAvxnmW_Pz86cfZ1_n5xZfV2fJ8jqJIu7kwUgmFJTKURpRVxpmRrMyBsbqslVLUpFRkBQqWSVmi5KhUaXIc8qQ18lny-qC7b1zQo19BsyyLdkW1LBKrA1E52Oq9tzvwN9qB1bcbzq81-M5iY7SgyFnJK1UBZlBgYaSkWGQyl7LGHKLWx_G2vtyZCqNJHpqJ6PSktRu9dteayyKl8ZNmybtRwLur3oRO72xA0zTQGtffvptnqRJyQN_8gz6c3UitISZg29rFe3EQ1ctMKq5kTtNILR6g4qjMzmIsrtrG_UnA-0lAZDrzp1tDH4JeXX7_f_bi15R9e8RuDDTdJrimHyoxTMHsAMbKDSFW673JjOqhN-7c0ENv6LE3Ytir4w-6D7prBv4X5OUKjQ</recordid><startdate>20131007</startdate><enddate>20131007</enddate><creator>Hughes, Alun D</creator><creator>Bathula, Raj</creator><creator>Park, Chloe</creator><creator>Tillin, Therese</creator><creator>Wit, Nicholas</creator><creator>McG Thom, Simon</creator><creator>Chaturvedi, Nish</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20131007</creationdate><title>Microcirculatory rarefaction in South Asians - 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We compared the retinal microcirculation in a population-based sample of 287 middle-aged adults (144 European 143 South Asian) matched for age and sex. Retinal photographs were taken and analysed using a validated semi-automated program and microvascular measures were compared. Blood pressure, anthropometry and fasting bloods were also measured. South Asians had significantly fewer arteriolar and venular vessels and bifurcations. Arterioles and venules were longer and venules were also more tortuous in South Asians. These differences were not explained by adjustment for traditional risk factors including blood pressure, body mass index, diabetes or measures of insulin resistance. People of South Asian descent have rarefaction of the retinal microcirculation compared to age-sex matched individuals of European descent. Reduced microvascular density could contribute to the elevated risk of CVD and impaired glucose tolerance in South Asian people.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>24116136</pmid><doi>10.1371/journal.pone.0076680</doi><tpages>e76680</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | PloS one, 2013-10, Vol.8 (10), p.e76680-e76680 |
| issn | 1932-6203 1932-6203 |
| language | eng |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adults Aged Anthropometry Arterioles Arterioles - pathology Arterioles - physiopathology Asian people Asians Asians - statistics & numerical data Atherosclerosis Bifurcations Blood Blood Glucose - metabolism Blood Pressure Blood vessels Body mass Body mass index Body size Cardiovascular disease Cardiovascular diseases Cardiovascular Diseases - blood Cardiovascular Diseases - ethnology Cardiovascular Diseases - physiopathology Comparative analysis Coronary vessels Descent Diabetes Diabetes mellitus Diabetes Mellitus - blood Diabetes Mellitus - ethnology Diabetes Mellitus - physiopathology Diabetic retinopathy Ethnicity Family medical history Fasting - blood Female Glucose tolerance Glycated Hemoglobin A - metabolism Health risks Humans Hypertension Insulin Insulin - blood Insulin resistance Lipids - blood Male Medicine Microcirculation Microvasculature Middle Aged Multivariate Analysis Population Primary care Rarefaction Regression Analysis Retina Retinal Vessels - pathology Retinal Vessels - physiopathology Risk analysis Risk Assessment - methods Risk Assessment - statistics & numerical data Risk Factors Sex Venules - pathology Venules - physiopathology Whites - statistics & numerical data |
| title | Microcirculatory rarefaction in South Asians - a potential mechanism for increased cardiovascular risk and diabetes |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T08%3A55%3A53IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Microcirculatory%20rarefaction%20in%20South%20Asians%20-%20a%20potential%20mechanism%20for%20increased%20cardiovascular%20risk%20and%20diabetes&rft.jtitle=PloS%20one&rft.au=Hughes,%20Alun%20D&rft.date=2013-10-07&rft.volume=8&rft.issue=10&rft.spage=e76680&rft.epage=e76680&rft.pages=e76680-e76680&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0076680&rft_dat=%3Cgale_plos_%3EA478387502%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1440074314&rft_id=info:pmid/24116136&rft_galeid=A478387502&rft_doaj_id=oai_doaj_org_article_60c31b3d8dac4a9c9e770c947577fc5a&rfr_iscdi=true |