Meta-analysis identifies NF-κB as a therapeutic target in renal cancer

To determine the expression patterns of NF-κB regulators and target genes in clear cell renal cell carcinoma (ccRCC), their correlation with von Hippel Lindau (VHL) mutational status, and their association with survival outcomes. Meta-analyses were carried out on published ccRCC gene expression data...

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Veröffentlicht in:	PloS one 2013-10, Vol.8 (10), p.e76746
Hauptverfasser:	Peri, Suraj, Devarajan, Karthik, Yang, Dong-Hua, Knudson, Alfred G, Balachandran, Siddharth
Format:	Artikel
Sprache:	eng
Schlagworte:	Bioinformatics Cancer Cancer therapies Carcinoma, Renal Cell - genetics Carcinoma, Renal Cell - metabolism Cell survival Clear cell-type renal cell carcinoma Correlation Cysteine Endopeptidases - genetics Cysteine Endopeptidases - metabolism Deregulation Exploitation Gelatinase B Gene expression Gene Expression Regulation, Neoplastic Gene Regulatory Networks Genes Humans Hypoxia I-kappa B Kinase - genetics I-kappa B Kinase - metabolism Immunohistochemistry Inflammation Interferon Interferons - genetics Interferons - metabolism Kidney cancer Kidney Neoplasms - genetics Kidney Neoplasms - metabolism Kidneys Kinases Malignancy Matrix Metalloproteinase 9 - genetics Matrix Metalloproteinase 9 - metabolism Medical prognosis Meta-analysis Metastasis Mutation NF-kappa B - genetics NF-kappa B - metabolism NF-κB protein Oligonucleotide Array Sequence Analysis Patients Prognosis Regulators Signal Transduction - genetics Signaling Signatures Statistical methods Superoxide dismutase Superoxide Dismutase - genetics Superoxide Dismutase - metabolism Survival Survival Analysis Therapeutic applications Transcription factors Transcriptome Tumorigenesis Tumors VHL protein Von Hippel-Lindau Tumor Suppressor Protein - genetics Von Hippel-Lindau Tumor Suppressor Protein - metabolism
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