Drug screening identifies niclosamide as an inhibitor of breast cancer stem-like cells

The primary cause of death from breast cancer is the progressive growth of tumors and resistance to conventional therapies. It is currently believed that recurrent cancer is repopulated according to a recently proposed cancer stem cell hypothesis. New therapeutic strategies that specifically target...

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Veröffentlicht in:	PloS one 2013-09, Vol.8 (9), p.e74538-e74538
Hauptverfasser:	Wang, Yu-Chi, Chao, Tai-Kuang, Chang, Cheng-Chang, Yo, Yi-Te, Yu, Mu-Hsien, Lai, Hung-Cheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Antiparasitic agents Apoptosis Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - pathology Cancer Cancer screening Cancer therapies Cell Line, Tumor Cell Proliferation - drug effects Cell Separation Cell surface Chemotherapy Clinical trials Dehydrogenases Drug evaluation Drug Evaluation, Preclinical Drug screening Drug Screening Assays, Antitumor Epigenetics Female Flow cytometry Growth factors Gynecology High-Throughput Screening Assays Humans Hypotheses In vivo methods and tests Laboratories Medical research Metastasis Mice Mice, SCID Neoplastic Stem Cells - drug effects Neoplastic Stem Cells - pathology Niclosamide Niclosamide - pharmacology Niclosamide - therapeutic use Obstetrics Oct-4 protein Population Recurrence (Disease) Screening Side-Population Cells - drug effects Side-Population Cells - metabolism Side-Population Cells - pathology Signal Transduction - drug effects Small Molecule Libraries - pharmacology Spheroids Spheroids, Cellular - drug effects Spheroids, Cellular - pathology Stem cell transplantation Stem cells Surface markers Tumor cell lines Tumorigenicity Tumors
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