Subcellular RNA sequencing reveals broad presence of cytoplasmic intron-sequence retaining transcripts in mouse and rat neurons

Recent findings have revealed the complexity of the transcriptional landscape in mammalian cells. One recently described class of novel transcripts are the Cytoplasmic Intron-sequence Retaining Transcripts (CIRTs), hypothesized to confer post-transcriptional regulatory function. For instance, the ne...

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Veröffentlicht in:	PloS one 2013-10, Vol.8 (10), p.e76194
Hauptverfasser:	Khaladkar, Mugdha, Buckley, Peter T, Lee, Miler T, Francis, Chantal, Eghbal, Mitra M, Chuong, Tina, Suresh, Sangita, Kuhn, Bernhard, Eberwine, James, Kim, Junhyong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bioinformatics Biology Cardiomyocytes Cytoplasm Cytoplasm - metabolism Dendrites Dendrites - metabolism Embedding Gene expression Gene regulation Gene sequencing Genes Genomes Genomics Hippocampus Interleukin 1 Introns Localization Mammalian cells Mice Neurons Neurons - metabolism Nucleotide sequence Organ Specificity - genetics Pediatrics Platelets Post-transcription Proteins Rats Regulatory sequences Retention Ribonucleic acid RNA RNA - genetics RNA - metabolism RNA sequencing RNA Splicing RNA, Messenger - genetics RNA, Messenger - metabolism RNA, Untranslated - genetics RNA, Untranslated - metabolism Splicing Transcription, Genetic Translation Translation (Genetics)
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