An antimicrobial peptidomimetic induces Mucorales cell death through mitochondria-mediated apoptosis

The incidence of mucormycosis has dramatically increased in immunocompromised patients. Moreover, the array of cellular targets whose inhibition results in fungal cell death is rather limited. Mitochondria have been mechanistically identified as central regulators of detoxification and virulence in...

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Veröffentlicht in:	PloS one 2013-10, Vol.8 (10), p.e76981-e76981
Hauptverfasser:	Barbu, E Magda, Shirazi, Fazal, McGrath, Danielle M, Albert, Nathaniel, Sidman, Richard L, Pasqualini, Renata, Arap, Wadih, Kontoyiannis, Dimitrios P
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcysteine - pharmacology Amino Acid Motifs Antibiotic resistance Antibiotics Antifungal agents Antimicrobial Cationic Peptides - chemical synthesis Antimicrobial Cationic Peptides - pharmacology Apoptosis Apoptosis - drug effects Biochemistry Cancer Candida albicans Caspase Cell death Cysteine Depolarization Detoxification Enzymatic activity Fungal infections Fungi Fungicidal activity Fungicides Germination Humans Immunocompromised hosts Infections Infectious diseases Internal medicine Laboratories Ligands Membrane potential Membrane Potential, Mitochondrial - drug effects Microbial drug resistance Microbial Sensitivity Tests Microbial Viability - drug effects Mitochondria Mitochondria - drug effects Mitochondria - metabolism Mucorales Mucorales - drug effects Mucorales - isolation & purification Mucorales - metabolism Mucormycosis Mucormycosis - microbiology Mycoses Obesity Oncology Oxygen Peptides Peptidomimetics - chemical synthesis Peptidomimetics - pharmacology Reactive oxygen species Reactive Oxygen Species - agonists Reactive Oxygen Species - antagonists & inhibitors Reactive Oxygen Species - metabolism Regulators Rods Spores, Fungal - drug effects Spores, Fungal - growth & development Spores, Fungal - metabolism Viability Virulence
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