miR-125b acts as a tumor suppressor in breast tumorigenesis via its novel direct targets ENPEP, CK2-α, CCNJ, and MEGF9

MicroRNAs (miRNAs) play important roles in diverse biological processes and are emerging as key regulators of tumorigenesis and tumor progression. To explore the dysregulation of miRNAs in breast cancer, a genome-wide expression profiling of 939 miRNAs was performed in 50 breast cancer patients. A t...

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Veröffentlicht in:	PloS one 2013-10, Vol.8 (10), p.e76247
Hauptverfasser:	Feliciano, Andrea, Castellvi, Josep, Artero-Castro, Ana, Leal, Jose A, Romagosa, Cleofé, Hernández-Losa, Javier, Peg, Vicente, Fabra, Angels, Vidal, Francisco, Kondoh, Hiroshi, Ramón Y Cajal, Santiago, Lleonart, Matilde E
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions Apoptosis Biological activity Biological effects Breast cancer Breast Neoplasms - genetics Breast Neoplasms - metabolism Cancer Casein Kinase II - genetics Casein Kinase II - metabolism Cell cycle Cell growth Cell Line Cell Proliferation Cell Transformation, Neoplastic - genetics Cluster Analysis Colorectal cancer Cyclins - genetics Cyclins - metabolism Drosophila Female Gene expression Gene Expression Profiling Gene Expression Regulation, Neoplastic Gene Knockdown Techniques Genes, Tumor Suppressor Genomes Glutamyl Aminopeptidase - genetics Glutamyl Aminopeptidase - metabolism Humans Identification Insects Kinases Leukemia Membrane Proteins - genetics Membrane Proteins - metabolism Metastasis MicroRNAs MicroRNAs - genetics MicroRNAs - metabolism miRNA Mortality Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Oncology Pathology Patients Prostate cancer Proteins Regulators Restoration RNA Interference Tumor suppressor genes Tumorigenesis Tumors
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