The heme oxygenase-1 inducer THI-56 negatively regulates iNOS expression and HMGB1 release in LPS-activated RAW 264.7 cells and CLP-induced septic mice

The nuclear DNA binding protein high mobility group box 1 (HMGB1) has recently been suggested to act as a late mediator of septic shock. The effect of ((S)-6,7-dihydroxy-1-(4-hydroxynaphthylmethyl)-1,2,3,4-tetrahydroisoquinoline alkaloid, also known as THI-56, in an experimental model of sepsis was...

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Veröffentlicht in:	PloS one 2013-10, Vol.8 (10), p.e76293
Hauptverfasser:	Park, Eun Jung, Jang, Hwa Jin, Tsoyi, Konstantin, Kim, Young Min, Park, Sang Won, Kim, Hye Jung, Lee, Jae Heun, Chang, Ki Churl
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Anti-Inflammatory Agents - administration & dosage Anti-Inflammatory Agents - pharmacology Antiinflammatory agents Cecum Cell Line Chromosomal proteins Creatinine Deoxyribonucleic acid Disease Models, Animal DNA Dose-Response Relationship, Drug GA-binding protein Gene Expression Regulation - drug effects Heme Heme oxygenase (decyclizing) Heme Oxygenase-1 - genetics Heme Oxygenase-1 - metabolism High mobility group proteins HMGB1 protein HMGB1 Protein - metabolism Infection Infiltration Inflammation Kinases Lethal dose Lipopolysaccharides Lipopolysaccharides - metabolism Lipopolysaccharides - pharmacology Lungs Macrophages Macrophages - drug effects Macrophages - metabolism Male Mice NF-E2-Related Factor 2 - metabolism Nitric oxide Nitric Oxide Synthase Type II - genetics Nitric Oxide Synthase Type II - metabolism Nitric-oxide synthase Oxygenase Protected animals Protein binding Proteins Protoporphyrin Protoporphyrin IX RNA Interference Rodents Sepsis Sepsis - drug therapy Sepsis - etiology Sepsis - genetics Sepsis - metabolism Sepsis - mortality Septic shock siRNA Tetrahydroisoquinoline Tetrahydroisoquinolines - administration & dosage Tetrahydroisoquinolines - pharmacology Tumor necrosis factor-TNF Zinc Zinc protoporphyrin IX
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