A novel DNA vaccine technology conveying protection against a lethal herpes simplex viral challenge in mice

While there are a number of licensed veterinary DNA vaccines, to date, none have been licensed for use in humans. Here, we demonstrate that a novel technology designed to enhance the immunogenicity of DNA vaccines protects against lethal herpes simplex virus 2 (HSV-2) challenge in a murine model. Po...

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Veröffentlicht in:	PloS one 2013-10, Vol.8 (10), p.e76407-e76407
Hauptverfasser:	Dutton, Julie L, Li, Bo, Woo, Wai-Ping, Marshak, Joshua O, Xu, Yan, Huang, Meei-li, Dong, Lichun, Frazer, Ian H, Koelle, David M
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Analysis Animal models Animals Antibodies, Viral - immunology Antigens Antigens, Viral - immunology Clinical trials Codon Codons Cytotoxicity Deoxyribonucleic acid DNA DNA vaccines Female Genomes Glycoprotein D Glycoproteins Herpes simplex Herpes Simplex - immunology Herpes Simplex - mortality Herpes Simplex - prevention & control Herpes viruses Herpesvirus 2, Human - genetics Herpesvirus 2, Human - immunology Immune response Immunogenicity Infections Infectious diseases Laboratories Latency Lymphocytes Lymphocytes B Lymphocytes T Medical research Medicine Melanoma Mice Optimization Plasmids Polynucleotides Proteasomes Proteins T cells T-Lymphocyte Subsets - immunology Technology Technology application Ubiquitin Ubiquitination Vaccines Vaccines, DNA - administration & dosage Vaccines, DNA - immunology Veterinary medicine Viral envelope proteins Viral Envelope Proteins - genetics Viral Envelope Proteins - immunology Viral Vaccines - administration & dosage Viral Vaccines - genetics Viral Vaccines - immunology Virology Viruses West Nile virus
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