Evaluation of glutathione S-transferase GSTM1 and GSTT1 deletion polymorphisms on type-2 diabetes mellitus risk

Due to the activity of GSTs in the detoxification of oxidative stress products, deletion polymorphisms of GSTM1 and GSTT1 may contribute to susceptibility to T2DM, since B-cells express very low levels of antioxidant enzymes. Recently, some studies have shown an association between GSTM1-null/GSTT1-...

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Veröffentlicht in:	PloS one 2013-10, Vol.8 (10), p.e76262
Hauptverfasser:	Pinheiro, Denise S, Rocha Filho, César R, Mundim, Cláudia A, Júnior, Paulo de Marco, Ulhoa, Cirano J, Reis, Angela A S, Ghedini, Paulo C
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Antioxidants Antioxidants (Nutrients) Beta cells Biochemistry Blood Blood glucose Blood pressure Brazil Cancer Case-Control Studies Cholesterol Clonal deletion Complications Detoxification Diabetes Diabetes mellitus Diabetes Mellitus, Type 2 - genetics Diabetes Mellitus, Type 2 - metabolism Diabetics Dyslipidemia Enzymes Female Gene deletion Gene polymorphism Genes Genetic aspects Genetic markers Genetic Predisposition to Disease Genotype Genotype & phenotype Genotypes Glucose Glutathione Glutathione transferase Glutathione Transferase - genetics Glycosylated hemoglobin GSTM1 protein GSTT1 protein Health risks Hemoglobin Humans Linear analysis Lipoproteins (very low density) Male Medical research Middle Aged Molecular biology Oxidative stress Parameters Pathogenesis Patients Polymorphism Polymorphism, Genetic Population Risk Risk factors Sequence Deletion Thiols Triglycerides Type 2 diabetes
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