Increased Cytoplasmic Localization of p27kip1 and Its Modulation of RhoA Activity during Progression of Chronic Myeloid Leukemia

The role of p27kip1 in Chronic Myeloid Leukemia (CML) has been well studied in relation to its function as a cell cycle inhibitor. However, its cytoplasmic function especially in CML remains to be seen. We studied the localization of p27kip1 and its function during the progression of CML from chroni...

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Veröffentlicht in:	PloS one 2013-10, Vol.8 (10), p.e76527
Hauptverfasser:	Roy, Anita, Lahiry, Lakshmishri, Banerjee, Debasis, Ghosh, Malay, Banerjee, Subrata
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Bone marrow CD34 antigen Cell cycle Cell survival Cells (biology) Chronic myeloid leukemia Cyclin-dependent kinase inhibitor p27 Cytoplasm Gene expression Genomics Guanosine triphosphate Hematology Imatinib Kinases Leukemia Ligands Localization Mutation Myeloid leukemia Nuclear physics Phase transitions Phosphorylation Progenitor cells Proteins RhoA protein Signal transduction Stem cells
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