Associations of ACE gene insertion/deletion polymorphism, ACE activity, and ACE mRNA expression with hypertension in a Chinese population

The present study was designed to explore the association of angiotensin converting enzyme (ACE) gene insertion/deletion (I/D, rs4646994) polymorphism, plasma ACE activity, and circulating ACE mRNA expression with essential hypertension (EH) in a Chinese population. In addition, a new detection meth...

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Veröffentlicht in:	PloS one 2013-10, Vol.8 (10), p.e75870
Hauptverfasser:	He, Qingfang, Fan, Chunhong, Yu, Min, Wallar, Gina, Zhang, Zuo-Feng, Wang, Lixin, Zhang, Xinwei, Hu, Ruying
Format:	Artikel
Sprache:	eng
Schlagworte:	ACE protein Adjustment Angiotensin Angiotensin converting enzyme Angiotensins Asian Continental Ancestry Group - genetics Cardiovascular disease Diabetes Disease control Disease prevention Enzymes Epidemiology Ethical standards Exercise Family medical history Female Fluorescence Gene deletion Gene expression Gene Expression Regulation, Enzymologic Gene polymorphism Genes Genetic aspects Genetic polymorphisms Genetic screening Genetic testing Genotype & phenotype Genotypes Health care Humans Hypertension Hypertension - blood Hypertension - enzymology Hypertension - genetics INDEL Mutation Informed consent Insertion Logistic Models Male Medical research Messenger RNA Middle Aged Multivariate Analysis Peptidyl-dipeptidase A Peptidyl-Dipeptidase A - blood Peptidyl-Dipeptidase A - genetics Polymerase chain reaction Polymorphism Population studies Public health Quantitative genetics Regression analysis Reverse transcription RNA, Messenger - genetics RNA, Messenger - metabolism Studies Transcription (Genetics)
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