Netazepide, a gastrin receptor antagonist, normalises tumour biomarkers and causes regression of type 1 gastric neuroendocrine tumours in a nonrandomised trial of patients with chronic atrophic gastritis

Autoimmune chronic atrophic gastritis (CAG) causes hypochlorhydria and hypergastrinaemia, which can lead to enterochromaffin-like (ECL) cell hyperplasia and gastric neuroendocrine tumours (type 1 gastric NETs). Most behave indolently, but some larger tumours metastasise. Antrectomy, which removes th...

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Veröffentlicht in:	PloS one 2013-10, Vol.8 (10), p.e76462-e76462
Hauptverfasser:	Moore, Andrew R, Boyce, Malcolm, Steele, Islay A, Campbell, Fiona, Varro, Andrea, Pritchard, D Mark
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Analysis Animal models Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Benzodiazepinones - pharmacology Benzodiazepinones - therapeutic use Bioavailability Biological markers Biomarkers Biomarkers - blood Biomarkers - metabolism Biopsy Cell constituents Cell culture Cholecystokinin Chromogranin A - blood Clinical trials Drug dosages Endoscopy Female Gastric Mucosa - metabolism Gastric Mucosa - pathology Gastrin Gastrins - blood Gastritis Gastritis, Atrophic - complications Gastroenterology Gastroscopy Gene expression Histidine Histidine decarboxylase Humans Hyperplasia Male Matrilysin Matrix metalloproteinase Medical research Medicine Metalloproteinase Middle Aged Nets Neuroendocrine tumors Neuroendocrine Tumors - complications Neuroendocrine Tumors - drug therapy Neuroendocrine Tumors - pathology Patients Phenylurea Compounds - pharmacology Phenylurea Compounds - therapeutic use Physiology Receptor, Cholecystokinin B - antagonists & inhibitors Rodents Stomach Neoplasms - complications Stomach Neoplasms - drug therapy Stomach Neoplasms - metabolism Stomach Neoplasms - pathology Surveillance Treatment Outcome Trinucleotide repeats Tumor Burden Tumors
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